With the start of the Korean War, she recommissioned on 26 January 1951. Naifeh left San Diego on 16 April, assigned to the United Nations Escort and Blockade Force. She took station off Songjin Harbor, North Korea, on 28 June. The next months were occupied in shelling Communist military and logistics facilities, along with patrol action to clear the area of floating mines, junks, and possible submarines. She then screened escort carrier and off the west coast of Korea. Naifeh returned to San Francisco in November 1951. From early March 1952 to July, she was engaged in training exercises off the West Coast. In early July, the destroyer escort sailed from San Diego for Korea to rejoin Task Force 95, Blockade and Escort Group. Naifeh was assigned to the northeast coast of Korea in the Songjin-Chongjin area. Here she fired on enemy shore positions, railroads, and industrial targets. Once bracketed by enemy shore fire, she successfully maneuvered out of range. With other assignments, she aided Republic of Korea Navy torpedo boats in interdiction missions against enemy supply lines. In late fall, Naifeh was flagship of the Wonsan Element Commander, protecting United States and Korean minesweepers and firing on shore targets. When was hit by artillery fire, Naifeh provided protective counter-battery fire as she laid a smokescreen to cover her withdrawal. In addition to blockade duty, the destroyer escort fired on North Korean supply movements in the Wonsan area. She returned to San Diego in December 1952.
Cold War
Naifeh again deployed to WestPac in mid-November 1953, operating off Japan, Okinawa, and Taiwan. May 1954 was spent with Marines conducting landing exercises off Pusan, Korea. She left Sasebo on 7 June 1954, arriving at San Diego on 26 June for a summer in operational training off the West Coast, highlighted by PACTRAEX and a visit to Seattle, Washington. Naifeh left San Diego on 21 November, arriving at Yokosuka on 9 December for patrol duty off the eastern coast of Korea and anti-submarine training. She assisted in the evacuation of the Tachen Islands in late January and February 1955, and returned to San Diego on 1 June. In early March 1956, the ship sailed for her fourth WestPac deployment. Based at Guam, the ship acted as a search and rescue ready duty ship and participated in five surveillance patrols of the Northern Marianas, Bonin, and Caroline Islands before returning to Long Beach on 24 August. The remainder of 1956 and early 1957 were occupied with training operations off the California coast. Leaving Long Beach, the destroyer escort once again deployed to the western Pacific, arriving at Guam on 30 April. In the first part of May, Naifeh made a patrol in the Bonin Islands. She departed Guam on 18 May and sailed for Sasebo, where she arrived on 23 May. She operated out of Sasebo and Subic Bay on patrol duties for the rest of her deployment until 12 July, when she departed Yokosuka and sailed to San Diego, arriving there on 28 July. Naifeh then engaged in coastal operations off the West Coast until 17 June 1960, when she decommissioned at San Francisco. Berthed at Mare Island until 1 January 1966, when she was struck from the Naval Vessel Register, she was towed to San Diego in early 1966 for stripping prior to being used as a target to destruction. In July, Naifeh was sunk as a target off San Clemente Island by a combination of naval gunfire and aircraft.
Honors
Naifeh received three battle stars for Korean War service.