Tadeusz Kamil Marcjan Żeleński was born on 21 December 1874 in Warsaw, to Wanda, née Grabowska, who was from a Frankist family, and Władysław Żeleński, a prominent composer and musician. Tadeusz's cousin was the notable Polish neo-romantic poet Kazimierz Przerwa-Tetmajer. Because higher education in Polish was forbidden in Warsaw under Russian rule, in 1892 Żeleński left for Kraków, in Austrian-ruled Galicia, where he enrolled at the Jagiellonian University medical school. Completing his studies in 1900, Żeleński began medical practice as a pediatrician. In 1906 he opened a practice as a gynaecologist, which gave him financial freedom. The same year, he co-organised the famous Zielony Balonikcabaret, which gathered notable personalities of Polish culture, including his brother Edward and Jan August Kisielewski, Stanisław Kuczborski, Witold Noskowski, Stanisław Sierosławski, Rudolf Starzewski, Edward Leszczyński, Teofil Trzciński, Karol Frycz, Ludwik Puget, Kazimierz Sichulski, Jan Skotnicki and Feliks Jasieński. In the sketches, poems, satirical songs, and short stories that he wrote for Zielony Balonik, Boy-Żeleński criticized and mocked the conservative authorities and the two-faced morality of the city folk, but also the grandiloquent style of Młoda Polska and Kraków's bohemians. This earned him a reputation as the "enfant terrible" of Polish literature.
At the outbreak of World War I, Żeleński was conscripted into the Austro-Hungarian Army and served as medic to railway troops. After the war, he returned to Poland and, in 1922, moved to Warsaw. He did not return to his medical practice but instead focused entirely on writing. Working for various dailies and magazines, Boy-Żeleński soon became one of the authorities of the Polish liberal and democratic intelligentsia. He criticized the two-faced morality of the clergy, promoted the secularization of public life and culture, and was one of the strongest advocates for the equality of women. He was one of the first public figures in Poland to support the women's right to legal abortion. Also, Boy-Żeleński often fought in his essays against the Polish romantic tradition, which he saw as irrational and as seriously distorting the way Polish society thought about its past. In addition, Boy translated over 100 classics of French literature, which ever since have been considered among the best translations of foreign literature into Polish. In 1933, Boy-Żeleński was admitted to the prestigious Polish Academy of Literature.
After the outbreak of World War II, Boy-Żeleński moved to Soviet-occupied Lwów, where he stayed with his wife's brother-in-law. In Lviv, Boy joined the Soviet-led University as the head of the Department of French Literature. Criticized by many for his public and frequent collaboration with the Soviet occupation forces, he maintained contacts with many prominent professors and artists, who found themselves in the city after the Polish Defensive War. He also took part in creating the Communist propaganda newspaper Czerwony Sztandar and became one of the prominent members of the Society of Polish Writers. After Nazi Germany broke the German–Soviet treaty and attacked the USSR and the Soviet-held Polish Kresy, Boy remained in Lwów. The city was captured on the night of 4 July 1941; he was arrested and taken to the Wulka hills where he was murdered for being "a Soviet spy", together with 45 other Polish professors, artists and intelligentsia in what became known as the massacre of Lviv professors.