Mason's YouTube videos, where he writes as Thunderf00t, have often drawn attention. A 2012 journal article stated that Thunderf00t's channel and P.Z. Myers' blog were "among the two most popular secularist hubs online." Mason has used his online persona to critically examine a range of topics, including proposals to build roads surfaced with glass solar panels. He has also attracted media attention for his criticisms of Anita Sarkeesian and hyperloops. In 2015, Jenny Keller, who ran the YouTube channel "Laughing Witch", attempted to get Mason fired by sending letters to his employer. Keller claimed that these efforts were intended to pressure Mason to change what she considered sexist and Islamophobic content on his channel. After promoting the campaign online, Keller eventually provoked a response from Mason, who posted a series of videos scrutinizing Keller and the Bowie, Maryland-based company she runs with her husband, Porcelain Tub Restoration. These videos led to many of Mason's fans posting negative reviews online for that company. On several occasions, Mason has made guest appearances on the Drunken Peasants Podcast.
Creationism
Through his YouTube account Thunderf00t, Mason produced a series of videos titled "Why do people laugh at creationists?", focusing primarily on Kent Hovind's arguments in public seminars. Sociologist Richard Cimino has described the tone of these videos as "that of the professional, well-educated, and articulate British academic expert exposing—in voiceover—the irrational behavior and attitudes of the believer." Mason debated with VenomFangX, a YouTube blogger who supports creationism, in a series of public exchanges that lasted almost two years. The series also covered other creationists, such as Ray Comfort and intelligent design proponent Casey Luskin.
Mason, on his own and with some fellow technical workers, did original physical chemistry research into the nature of the alkali metals and their chemistry with oxygen and water. It has been known since the metals could be obtained in pure forms that they are explosive when dropped into water. It has long been thought this was caused by the dissociation of water by the metal, releasing hydrogen and oxygen which recombined in an explosion. Mason developed experimental methods and results that indicate the first reaction of alkali metals and water was coulombic in nature which shatters and drives the metal in an extremely pure state into the water, causing both further coulombic and water dissociation. This result developed in 2015 was completely new to chemistry. His research, supported by the YouTube community, has been published in the journal Nature Chemistry. On 5 June 2020, his research on solvated electrons dissolved in ammonia was published on the front page of the science journalScience.