PBRM1


Protein polybromo-1 also known as BRG1-associated factor 180 is a protein that in humans is encoded by the PBRM1 gene.

Structure and function

Component of the SWI/SNF-B chromatin-remodeling complex, which contains at least SMARCA4/BRG1, SMARCB1/SNF5/INI1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, and actin.
Chicken PB1 possesses 5 bromodomains, 2 bromo-adjacent homology domains, and 1 truncated high-mobility group motif. cPB1 is also homologous to yeast Rsc1, Rsc2, and Rsc4, essential proteins that are required for cell cycle progression through mitosis.

Clinical significance

PBRM1 is a tumor suppressor gene in many cancer subtypes. Mutations are especially prevalent in clear cell renal cell carcinoma.