Clear cell renal cell carcinoma

Genetics

Cytogenetics

• Alterations of chromosome 3p segments occurs in 70 – 90% of CCRCCs
• Inactivation of von Hippel-Lindau disease gene by gene mutation and promoter hypermethylation
• Gain of chromosome 5q
• Loss of chromosomes 8p, 9p, and 14q

  Molecular genetics

Histogenesis

Microscopy

Epidemiology

• Most commonly affects male patients in their sixties and seventies.
• Majority of CCRCC arise sporadically.
• Only 2 – 4% of the cases presenting as part of an inherited cancer syndrome, such as von Hippel-Lindau syndrome.

  Images