In his first season with Lille, Delpierre made few appearances but helped in the club's promotion to Ligue 1. Delpierre played more regularly in his second season, helping Lille finish third and thereby qualify for the UEFA Champions League. Delpierre continued to perform well for Lille though the club finished at a lower position in the league every season.
Stuttgart
Delpierre was signed by VfB Stuttgart on a free transfer after Lille refused to grant him a contract extension. Stuttgart struggled during the 2004–05 and 2005–06 seasons, but Delpierre began to improve under the tutelage of coach Armin Veh. The following season, during which he missed only one game through illness, the French defender formed an almost impenetrable barrier alongside Fernando Meira at the heart of the Stuttgart defence. Matthieu has also been a vital cog in Stuttgart's success in the 2006–07 DFB-Pokal, in which the team conceded only three goals before losing the final to Nürnberg. On 19 May 2007, Delpierre won the German Bundesliga with Stuttgart, playing a significant part in their success. His defensive performances attracted the attention of Arsenal and Bayern Munich and also French clubs Marseille and Saint-Étienne. However, he remained at Stuttgart, extending his contract until the summer of 2012. On 1 December 2009, Delpierre was appointed the new captain of VfB Stuttgart by Markus Babbel. On 12 January 2012 he asked Bruno Labbadia to appoint another player. Delpierre joined Hoffenheim on a free transfer at the end of the 2011–12 season. He spent 18 months with Hoffenheim before moving to FC Utrecht in January 2014.
Move to Australia
On 7 July 2014, A-League club Melbourne Victory announced the signing of Delpierre on a one-year deal. On 10 October 2014, Delpierre scored the first goal of the 2014–15 A-League season in the Victory's first round match against the Western Sydney Wanderers, scoring from a Guilherme Finklerfree kick in just the 8th minute of the match. The Victory eventually won the match 4–1. On 1 May 2015, Delpierre extended his contract with Melbourne Victory for one more year. Delpierre made 53 appearances in all competitions for the Victory during his two seasons in the A-League, scoring once. On 26 April 2016, Delpierre announced his retirement from professional football at the age of 35, having completed 17 seasons since his debut with Lille in 1999.
International career
Delpierre was called up to the senior France team in March 2008 but was ultimately never capped at that level.
