Lysergol
Lysergol is an alkaloid of the ergoline family that occurs as a minor constituent in some species of fungi, and in the morning glory family of plants, including the hallucinogenic seeds of Rivea corymbosa, Argyreia nervosa and Ipomoea violacea. Lysergol is not a controlled substance in the USA. Its possession and sale is also legal under the U.S. Federal Analog Act because it does not have a known pharmacological action or a precursor relationship to LSD, which is a controlled substance. However, lysergol is an intermediate in the manufacture of some ergoloid medicines.
Lysergol can be synthesised using a tandem reaction to construct the piperidine skeleton and a rhodium-catalyzed annulation in the late-stage indole formation.
