List of ambassadors of the United States to Spain
This is a list of United States ambassadors to Spain from 1779 to the present day.
Ambassadors
| Representative | Appointment date | Title | Presentation of Credentials | Termination of Mission |
| John Jay | September 29, 1779 | Minister Plenipotentiary | N/A | ~May 20, 1782 |
| William Carmichael | N/A | Chargé d'Affaires | February 20, 1783 | Presented recall September 5, 1794 |
| William Short | May 28, 1794 | Minister Resident | September 7, 1794 | Left post November 1, 1795 |
| David Humphreys | May 20, 1796 | Minister Plenipotentiary | September 10, 1797 | Probably presented recall soon after December 28, 1801 |
| Charles Pinckney | June 6, 1801 | Minister Plenipotentiary | January–March 1802 | Presented recall October 25, 1804 |
| James Bowdoin III | November 22, 1804 | |||
| George W. Erving | N/A | Chargé d'Affaires ad interim | October 1805 | February 1810 |
| George W. Erving | August 10, 1814 | Minister Plenipotentiary | August 24, 1816 | Left post May 15, 1819 |
| John Forsyth | February 16, 1819 | Minister Plenipotentiary | May 18, 1819 | Had farewell audience on March 2, 1823 |
| Hugh Nelson | January 15, 1823 | Minister Plenipotentiary | December 4, 1823 | Presented recall July 10, 1825 |
Note: In 1825 the ministry was upgraded to Envoy Extraordinary and Minister Plenipotentiary.
Note: In August 1913, the title of the office was changed to Ambassador Extraordinary and Plenipotentiary. This required a new commission.''