CCDC82


Coiled-Coil Domain Containing protein 82 is a protein that in humans, is encoded for by the gene of the same name, CCDC82. The CCDC82 gene is expressed in nearly all of human tissues at somewhat low rates. As of today, there are no patents involving CCDC82 and the function remains unknown.

Gene

CCDC82 is located on chromosome 11 at 11q21.5.
It contains two domains of unknown function, DUF4196 and DUF4211. The DNA sequence is 37,155 base pairs long and contains 7 exons.

Homology

CCDC82 is present in many orthologs. It is conserved throughout other mammals, reptiles, birds and bony fish. It is not found in invertebrates, bacteria or fungi. There are no paralogs.
Scientific nameCommon nameDate of divergenceAccession numberLengthPercent identityPercent similarity
Pan troglodytesChimpanzee6.3 MyaXP_001147806.1544 aa60.899
Gorilla gorilla gorillaGorilla8.8 MyaXP_004052053.1521 aa56.291
Pongo abeliiOrangutan15.7 MyaNP_003253075.1343 aa95.398
Nomascus leucogenysCrested gibbon20.4 MyaXP_003253075.1554 aa57.894
Papio anubisOlive baboon29 MyaXP_003910631.1542 aa5286
Callithrix jacchusMarmoset42.6 MyaXP_002754732.1526 aa51.286
Mus musculusMouse92.3 MyaNP_079810.2518 aa39.774
Rattus norvegicusBrown rat92.3 MyaNP_001007661.1516 aa37.471
Canis lupus familiarisDog94.2 MyaXP_542232.2520 aa4679
Bos taurusCow94.2 MyaNP_001039559.2522 aa42.474
Ailuropoda melanoleucaGiant panda94.2 MyaXP_002925755.1528 aa45.480
Loxodonta africanaAfrican bush elephant98.7 MyaXP_003415705.1521 aa40.475
Sarcophilus harrisiiTasmanian devil162.2 MyaXP_003764344.1518 aa36.970
Monodelphis domesticaGray short-tailed opossum162.2 MyaXP_001363143.1516 aa36.772
Ornithorhynchus anatinusPlatypus167.4 MyaXP_001511067.1505 aa26.670
Gallus gallusChicken296 MyaXP_423807.3460 aa24.356
Meleagris gallopavoWild turkey296 MyaXP_003203546.1462 aa21.570
Taeniopygia guttataZebra finch296 MyaXP_002198267.1575 aa2061
Anolis carolinensisCarolina anole296 MyaXP_003219357.1603 aa19.949
Xenopus tropicalisWestern clawed frog371.2 MyaXP_002935613.1462 aa2173

mRNA

Promoter

The predicted promoter for CCDC82 is located on the minus strand and spans from base pairs 96,122,963 to 96,123,587. It is 625 base pairs long.

Transcription factors

The transcription factors listed below are for the predicted promoter sequence and are located on the minus strand.
Detailed Family InformationSpanScore
Alternative splicing variant of FOXP148-641.00
Homeodomain transcription factor Otx234-50.992
Hypoxia-response Elements111-127.985
Homeobox A10/HOX 1.852-68.957
SRY box 980-104.947
Mesoderm posterior 1 and 242-62.937
c-Myc/Max heterodimer44-60.929
SAM pointed domain containing ets transcription factor27-47.923
cAMP-responsive element binding protein134-154.917
PR domain zinc finger protein 14138-152.912

Protein

The protein it encodes for is 344 amino acids in length. The protein itself is very acidic and is very rich in aspartic acid and glutamic acid. It is also very deficient in alanine, containing only two alanines in the entire sequence. The alanines are located adjacent to each other, amino acid number 233 and 234. Alanine 233 is highly conserved throughout the orthologs. The molecular weight is 40.0 kdal and the isoelectric point is 4.383

Expression

CCDC82 is found in nearly all tissues in the human body, however it is present in higher quantities in the skeletal muscles, adrenal cortex, and the trigeminal ganglion.

Post translational modifications

CCDC82 has several predicted phosphorylation sites. There are 32 predicted serine phosphorylation sites, 5 threonine, and 3 tyrosine.

Interactions

CCDC82 is known to interact with two proteins. It indirectly interacts with VHL, a gene that encodes for a tumor suppressor and ubiquitin protein ligase. It also interacts with EWSR1, which functions as a transcriptional repressor.

Clinical significance

CCDC82 is a circulat-responsive gene. Circulat is a product designed to restore systemic vascular health. It is a plant based product and taken by patients who suffer from diabetes or circulatory problems.

Possible function

Based on the information that CCDC82 is affected by the Circulat product it could be hypothesized that CCDC82 is involved in circulatory function. However, this is purely speculation.