Zydis
Zydis is a technology used to manufacture orally disintegrating tablets developed by R.P. Scherer Corporation. Zydis tablets dissolve in the mouth within 3 seconds.
History
Zydis technology was developed by R.P. Scherer Corporation in 1986. The technology's first commercial application was in August, 1993, when a new dosage form of Pepcidine from Merck & Co. was launched in Sweden.In November 1993 Imodium Lingual from Janssen Pharmaceutica was released in Germany with Zydis technology.
In December, 1996, the Food and Drug Administration approved Claritin RediTabs from Schering-Plough, the first prescription drug with Zydis technology sold in the U.S.
Technology
A Zydis tablet is produced by lyophilizing or freeze-drying thedrug in a matrix usually consisting of gelatin. The resulting product is very lightweight and fragile, and must be dispensed in a special blister pack.
Amipara et al., in their article "Oral disintirating tablet of antihypertensive drug" explain the technology's limitations:
The Zydis formulations consist of a drug physically trapped in a water-soluble matrix, which is freeze dried to produce a product that dissolves rapidly when placed in mouth. The ideal candidate for Zydis technology should be chemically stable and insoluble and particle size preferably less than 50 micron.
Water soluble drugs might form eutectic mixtures and not freeze adequately, so dose is limited to 60 mg and the maximum drug limit is 400 mg for water insoluble drug as large particle sizes might present sedimentation problems during manufacture.
Advantages and disadvantages
Advantages
Zydis tablets:- are convenient for the patients who have difficulty in swallowing ;
- are fast to absorb;
- don't require water to consume;
- have good taste ;
- don't provoke choking or suffocation;
- have high microbial resistance.
Disadvantages
- increased price due to cost-intensive production;
- sensitivity to moisture ;
- poor physical resistance ;
- limited ability to incorporate higher concentrations of active drug.
Fast dissolving drugs with Zydis technology
| Trade name | Active formula | Manufacturer | Indication |
| Ativan | Lorazepam | Valeant Pharmaceuticals | Anxiety disorders |
| Claritin RediTab | Loratadine | Schering-Plough | Allergy |
| Imodium | Loperamide | Johnson & Johnson | Diarrhea |
| Feldene melt | Piroxicam | Pfizer | Pain relief |
| Maxalt MLT | Rizatriptan | Merck & Co. | Headache |
| Motilium | Domperidone | Johnson & Johnson | Nausea and vomiting |
| Zelapar | Selegiline | Valeant Pharmaceuticals | Parkinson's disease, depression |
| Pepcid RPD | Famotidine | Johnson & Johnson | Peptic ulcer disease, gastroesophageal reflux disease |
| Zyprexa | Olanzapine | Eli Lilly and Company | Schizophrenia, bipolar disorder |
| Zofran ODT | Ondansetron | GlaxoSmithKline | Nausea and vomiting |
Data from "Fast Disintegrating Drug Delivery Systems: A Review with Special Emphasis on Fast Disintegrating Tablets".