Reyes began performing his poetry at 16 years old upon realizing the power of language after being called “joto,” a derogatory Spanish term used to refer togay men. Reyes' first publication was the result of his winning first place in a writing competition in San Jose. At age 17, he won the title for the 2005 South Bay Teen Grand SLAM Champion, repeating his win in 2006. In 2007, he was featured in a Youth Speaks documentary titled 2nd Verse: the Rebirth of Poetry. In 2009, he self-published his first chapbook, For Colored Boys Who Speak Softly, which garnered national and international acclaim. Musicians Carlos Santana and Harry Belafonte were early champions of Reyes' work. He has been anthologized in the collections Mariposas: A Modern Anthology of Queer Latino Poetry ; Queer in Aztlán: Chicano Male Recollections of Consciousness and Coming Out ; and Joto: An Anthology of Queer Xicano & Chicano Poetry. He and his work have also been featured in The Atlantic, the Huffington Post, Medium, Remezcla,, VICE, and Teen Vogue. In June 2016, Reyes premiered a solo staged reading of Prieto, his first autobiographical play, in collaboration with Guerrilla Rep Theater, Galería de la Raza, and Define American. In Prieto: Growing Up Queer and Undocumented, Reyes shared an account of his younger self understanding his dual queer and undocumented identity. Reyes was awarded an Undocupoets fellowship by Sibling Rivalry Press in 2017 and an Emerging Writers' fellowship in playwriting by Lambda Literary in 2018. Reyes' poem "Paisa" was featured in the eponymous short film directed by Dorian Wood and Graham Kolbeins in 2019. During the 2020 COVID-19 pandemic, Reyes launched his virtual #YosiBookClub and IG Live Writers' Series wherein he interviews prominent Latino authors in an effort to demystify the creative process. Among interviewees have been playwright and USC professor Luis Alfaro, VidaTV series creator Tanya Saracho, National Book Award finalist Kali Fajardo-Anstine, BuzzFeed contributor Curly Velasquez, former Goldman Sachs executive Julissa Arce, and noted poets Yesika Salgado, Karla Cornejo Villavicencio, Walter Thompson-Hernández, and Javier Zamora. In addition to his literary practice, Reyes has curated or participated in multidisciplinary art exhibitions, including Homegirrlz: Demos and Remixes,Migrating Sexualities: Unspoken Stories of Land, Body and Sex,We Never Needed Papers to Thrive, #UndocuJoy, and In Plain Sight. As a co-founder of La Maricolectiva, a grassroots performance community, Reyes has helped to support queer, undocumented poets and creatives. He is also associated with DreamersAdrift. In solidarity with the 2020 Black Lives Matter protests, Reyes educated the US Latino and undocumented communities on anti-blackness and systematic racism in Spanish via Univision and radio programs. Reyes has been recognized as one of "13 LGBT Latinos Changing the World" by The Advocate as well as a member of the OUT100 by Out Magazine.