In 1950 Holford, along with H Myles Wright produced a report for Cambridgeshire County Council titles 'Cambridge Planning Proposals'. A controversial report, much of his road proposals were never completed. This included his proposal to build a ring road around Cambridge, only sections of which were ever built. These sections include Perne Road, Brooks Road and Barnwell Road. The last of the three was due to link up to Milton Road via a new road bridge over Stourbridge Common but the strength of protests prevented this from ever being built. At Cambridge Railway Station the report also proposed a new footbridge linking East Cambridge directly to the railway station, with a proposed car park and bus stop on a site off Rustat Road opposite the current station. Despite numerous calls over the decades, an eastern entrance to Cambridge railway station has never been built.
Clarendon House
Holford designed significant individual buildings, including Clarendon House in Cornmarket Street, Oxford, which was built in 1956–57 for F.W. Woolworth. Sir Nikolaus Pevsner commended Clarendon House in Oxford as one of the best recent buildings in the city's main shopping streets and showing "how this kind of job can be done tactfully and elegantly."
In 1960 Holford redesigned part of the former RAF Mount Farm, Oxfordshire to form the new village of Berinsfield. The architectural historian Jennifer Sherwood criticised Holford's plan as "an opportunity missed... little more than a huge council estate... with brick semis and terraces of the most dismal kind, sprawled out aimlessly along dreary streets..."
From 1961 Holford presented a series of plans to solve road traffic congestion at Piccadilly Circus, some of which included a raised piazza for pedestrians above the ground-level traffic. This concept was kept alive for the rest of 60s, before eventually being terminated by Sir Keith Joseph and Ernest Marples in 1972. The key reason given was that Holford's scheme only allowed for a 20% increase in traffic, whereas the Government wanted 50%.
Holford is particularly noted for his redevelopment plan of the area around St Paul's Cathedral in London which had been devastated by aerial bombardment in The Blitz. Only part of Holford's concept was carried out 1961–67, foremost the Paternoster Square development between St Paul's churchyard and Newgate Street. Due to the undistinguished design of the individual buildings by other architects and the omission of some of Holford's features, the new Paternoster Square soon became very unpopular. Its presence immediately north of one of the capital's prime tourist attractions was widely considered grim and an embarrassment. A redevelopment competition was launched in 1986 and after numerous changes in plans and architects, the new Paternoster Square was completed in 2003.
Holford was a sought-after consultant outside the UK. In 1957 he was part of the committee selecting Lúcio Costa's plan for Brasília and in 1965–68 produced reports on the development of Durban in South Africa.
In the mid-1950s the Robert MenziesGovernment of Australia asked Holford to report on the planning and development of Canberra, which had become disorganised due to the Great Depression, World War II and post-war economic stringency. His report led to the creation of the National Capital Development Commission, which controlled Canberra's development 1957–89, when the city as it exists today was created. He also advised extensively on Canberra's planning and this advice was largely accepted by the NCDC and led to the evolution of Canberra into a city of car-based suburbs based on the British New Town concept. One unfortunate legacy is the NCDC's acceptance of his recommendation that the proposed new Parliament House be built on the banks of Lake Burley Griffin, rather than on Capital Hill. In 1978 the Parliament of Australia decided that Parliament House would be built on Capital Hill as proposed by its original planner Walter Burley Griffin. The use of the area that the Parliament House was to occupy under the Holford plan has never been fully resolved.