Clyburn was born in Detroit, Michigan, he attended Romulus Senior High School in Romulus, Michigan, where he averaged 10.7 points as a senior, earning the "Best Shooter" award. Clyburn began his college career at Marshalltown Community College, where he averaged 19.6 points and 8.7 rebounds per game as a sophomore. In one game, Clyburn had a 54-point outburst against Southeastern Community College. Clyburn earned first-team All-ICCAC honors and first-team All-Region XI accolades in 2010. In 2010, he transferred to the University of Utah, where he earned Second-Team Mountain West Conference honors and First-Team NABC All-District 17 accolades after leading the team in scoring and rebounding per game. Clyburn was ranked third in the Mountain West in both scoring and rebounding and ranked 92nd nationally in scoring. On April 12, 2011, he transferred again to Iowa State University and was forced to sit out the 2011–12 season as a redshirt. In his senior year at Iowa State, he was named Big 12 Newcomer of the Year and earned All-Big 12 Second Team honors. Clyburn led the team and ranked seventh in the Big 12 in scoring with 14.9 points per game.
On September 8, 2015, Clyburn signed with Hapoel Holon in Israeli Premier League. On April 25, 2016, Clyburn recorded 31 points, shooting 11-of-15 from the field, along with nine rebounds and three assists for 43 PIR in a 98–80 win over Maccabi Ashdod. He was subsequently named Israeli League Round 30 MVP. On May 1, 2016, Clyburn was named Israeli League Player of the Month after averaging 25.6 points, 10.6 rebounds and 4 assists in five games played in April. In 33 games played for Holon, Clyburn led the league in scoring with 20.9 points per game, to go with 8.2 rebounds, 2 assists and 1.4 steals per game. On June 3, 2016, Clyburn earned a spot in the All-Israeli League Second Team.
On August 5, 2016, Clyburn signed with Darüşşafaka of the Turkish Basketball Super League and the EuroLeague. On March 30, 2017, Clyburn recorded a season-high 26 points, shooting 9-of-14 from the field, along with seven rebounds in a 99–97 win over Brose Bamberg. Clyburn led Daçka to the 2017 EuroLeague Playoffs as the eighth seed, but they eventually were eliminated by Real Madrid in the Quarterfinals.
CSKA Moscow (2017–present)
On June 20, 2017, Clyburn signed a two-year contract with CSKA Moscow of the VTB United League and the EuroLeague. In 64 games played during the 2017–18 season, he averaged 11.9 points, 5.2 rebounds and 1.7 assists per game. Clyburn helped CSKA win the 2018 VTB United League Championship, winning his first career title. On January 17, 2019, Clyburn recorded 20 points, shooting 6-of-13 from the field, along with eight rebounds and two steals, leading CSKA to a 77–70 comeback win over FC Bayern Munich. Two days later, Clyburn was named EuroLeague Round 19 MVP. On May 9, 2019, Clyburn was named to the All-EuroLeague First Team. On May 19, 2019, Clyburn led CSKA win the 2019 EuroLeague Championship after scoring 20 points in the championship game against Anadolu Efes. He was named the EuroLeague Final Four MVP. On June 14, 2019, Clyburn signed a three-year contract extension with CSKA. On October 25, 2019, Clyburn has been ruled out for the rest of the season after he suffered an ACL injury in a match against Alba Berlin.
Personal life
Clyburn's younger brother, Kris is also a professional basketball player who currently plays in Poland for Astoria Bydgoszcz.