Atkin joined the Colorectal Cancer Unit at Cancer Research UK in St Mark's Hospital, and was made deputy director in 1997. She was made a senior lecturer at Imperial College London in 1997, reader in 2000 and professor in 2004. From 1994 she worked with Jane Wardle on a trial of flexible sigmoidoscopy that included endoscopic examination of the colon, reporting that 40% of colorectal cancers could be prevented by this intervention. She compared the screening to a Faecal occult blood test. In 2008 she moved to St Mary's Hospital, London, where she established the Cancer Screening and Prevention Research Group. The group researches bowel cancer and, ultimately, aims to reduce the number of people who die from the disease. Their 2010 paper outlining the results of the UK Flexible Sigmoidoscopy Screening Trial was the most frequently cited paper in The Lancet that year. The landmark study was a randomised controlled trial of almost 400,000 adults across 14 areas in the UK. If there were any polyps, people were referred for a colonoscopy. The strategy was rolled out by the UK National Screening Committee in 2011 and was expected to achieved complete population coverage in 2016. This was achieved with a £60 million investment from the UK government. It's estimated to prevent 5,000 cancer diagnoses and 3,000 deaths a year. They found an increased risk in bowel polyps from eating red meat. They examined the incidence and mortality for the following 17 years, finding that people involved in the screening had a 41% lower mortality. The bowel cancer screening test BowelScope can prevent 35% of bowel cancers. Atkin went on to create a Special Interest Group on Gastrointestinal and Abdominal Radiologists 1, which analysed the effectiveness of virtual colonoscopy. They found it was less invasive and more effective at finding precancerous polyps and bowel cancer. She researched the optimum timing of surveillance strategies for people who were at high risk of bowl cancer. Atkin established a patient-friendly process that would invite, screen and follow-up the whole population. She found that patients at risk of developing bowel cancer benefitted significantly from a follow-up colonoscopy. She served as an expert advisor for the National Institute for Health and Care Excellence Guidelines for Colonoscopic Surveillance. She served on several advisory committees and boards. She retired from Imperial College London in August 2018 and was made Emeritus Professor. She died on 2 October 2018.
