Graham was born in Yoakum, Texas. His father, Earl moved the family to Houston to get a job. Wayne was the batboy for the 1945 semi-pro Finger Furniture baseball team coached by his father.
Playing career
Graham attended Reagan High School in Houston and played college baseball at the University of Texas, where he played two seasons under coach Bibb Falk. Graham was signed by the Phillies as an amateur free agent in 1957. He played eleven years in pro ball, with the Phillies and Mets organizations. Graham was named Texas minor league player of the year in 1962 after hitting.311 for the Dallas-Fort Worth Rangers. Graham received two brief MLB call-ups in the early 1960s. In, he was recalled by the Phillies, playing in ten games for managerGene Mauch. Graham then appeared in twenty games for the “Amazin’ Mets”, under the tutelage of legendary skipper Casey Stengel. He batted.127 in 55 at-bats in his brief major league career.
Beginning in 1981, Graham turned San Jacinto into the nation's most dominant JUCO baseball team. After regular conference titles in Graham's first few seasons, the Gators became a dominant force in 1984 when they began a run of seven consecutive 50-win seasons and berths in the NJCAA World Series in Grand Junction, Colorado. After losing in the 1984 championship game, San Jacinto won three consecutive titles from 1985–87. After falling short again in 1988, the Gators went back-to-back in 1989–90. Those five national titles in six years eventually led to Graham being named Junior College Coach of the Century by Collegiate Baseball. In his 11 seasons at San Jacinto, Graham posted a 675-113 record, earned five national coach of the year awards, and produced countless professional players, most notably Roger Clemens and Andy Pettitte.
Rice
Graham took over at Rice in 1992. He inherited a program that had tallied only seven winning seasons in 78 years of Southwest Conference play and had only finished above fourth place once. As at San Jacinto, he turned the program into a national powerhouse. A program that had never before qualified for the NCAA Division I Baseball Tournament made 23 consecutive tournament appearances and won 20 consecutive regular-season or tournament conference championships in three different conferences. Rice has also been to the College World Series seven times. Graham's crowning achievement was the 2003 College World Series, in which Rice won its first national championship in any sport in its 91-year history. Not one to rest on his laurels, Graham quipped during a post-game interview, "We want to do it again." On April 16, 2016, Graham won his 1,100th Division I game. He has more than 1,600 wins as a collegiate head coach. Graham was also largely responsible for Rice's on-campus baseball stadium, Reckling Park, being built in 2000. In 2004, Graham once again presided over history, as three Rice pitchers were drafted in the first eight picks of the 2004 Major League Baseball Draft, the only time three teammates have ever been selected in the first round. Graham's Rice teams have produced first-round picks Jose Cruz, Jr., Matt Anderson, Lance Berkman, Bubba Crosby, Kenny Baugh, Jon Skaggs, David Aardsma, Philip Humber, Jeff Niemann, Wade Townsend, Joe Savery, and Anthony Rendon. Eight of those players have been pitchers, and Graham is known for developing players that went undrafted out of high school, such as Niemann and Townsend. During the 2017 season, despite finishing in 6th place in Conference USA, Graham led Rice to their 23rd consecutive NCAA Tournament. Needing to win the Conference USA tournament title to qualify for the NCAA tournament and to keep the streak alive, he led to Owls to the conference title. Rice won four consecutive games and rallied late in the championship to upset #11 nationally ranked Southern Miss 5-4 on a walk-off double. Graham never had a losing season as a high school or college coach until his final season at Rice, 2018. His contract was not extended after that season.