The original facade is Gothic and attributed to Domenico da Venezia 16th century. It is divided into four sections: the lower one has five arches in transoms, the second with arches in the center of an oculus, the third is smooth, the fifth is decorated with five statues.
Dome
The construction of the apse in the Cathedral of Vicenza had begun in 1482 to the design of Lorenzo da Bologna, but in 1531 it was still unfinished. Early, temporary, roofing was erected in 1540, as a result of the possibility that Vicenza might host the Church Council which in the end was held at Trent. Only in 1557 did the Comune of Vicenza receive the financial means necessary from the Republic of Venice, in the shape of a bequest left by Bishop Zeno at the beginning of the century, and were therefore able to set in motion the work’s completion. Andrea Palladio, the author of the new project, most probably drew up an overall design which was however executed in two phases: from 1558 to 1559 the main cornice was built over the windows and the drum raised, while from 1564 to January 1566 the dome itself was constructed. The characteristic form of the lantern, abstract and devoid of decoration, was replicated on the summit of the cupolas of San Giorgio Maggiore in Venice, and is also present in some of Palladio’s reconstructions of centrally planned antique temples, such as the Mausoleum of Romulus on the Via Appia. Since 1994, the dome, together with other Palladian buildings in and around Vicenza, has been part of the UNESCO World Heritage SiteCity of Vicenza and the Palladian Villas of the Veneto.
The bell tower
It is slightly detached from the church and placed in the street that runs along the south side of the cathedral. It rests on a 10th-century stone base, the bell tower dates from the twelfth century and has five bells, in the chord of Eb, the oldest still in place was cast in the seventeenth century.
Interior
Remarkable elements
; Left nave
The first chapel on the left, Thiene chapel with funerary monument to Lavinia Thiene, by Giulio Romano and on the right wall, a cenotaph with the arms of the Thiene family and Saint Cajetan.
Second chapel on the left, an oil on canvas by Alessandro Maganza: Adorazione della Vergine con gli Angeli 1581
Third chapel on the left dedicated to the Loschi family. Above the altarpiece are the arms of the family. Tombstones of Alfonso Loschi and Antonio Loschi.
The fourth chapel on the left shows an oil on canvas Madonna col bambino tra le Sante Maddalena e Lucia, by Bartolomeo Montagna
Fifth chapel on the left : Chapel of the Incoronata or Gonfalone built in 1426 by the ancient fraglia of S. Maria, transformed around 1591 in the Confraternity of the Gonfalone.
; Right nave
Chapel of the baptismal font - The present work dates from 1824. Work of the brothers Sguarise stone cutters on a drawing of the Antonian Bernati Bassanese. On the lid there is a small statue of Saint John the Baptist of Girolamo Albanese.
Chapel of St. James and St. Anthony the Great - Dormitio Virginis, polyptyque de Lorenzo Veneziano. On the left wall the sarcophagus of Tommaso and Giampietro de Proti.
Chapel of St. Jerome - The oldest one, founded in 1383 by Bishop Giovanni de Surdis, was then repeatedly remodeled, preserves today the two funerary monuments to Girolamo and Giovanni Battista Gualdo with the busts of the sarcophagus by Alessandro Vittoria.
Organ
In the last chapel on the right, there is the Mascioni opus 721 rod, built in 1955 and subsequently expanded. The instrument is electrically powered and its console, independent mobile, has three keyboards of 61 notes each and a concave-radial pedal of 32 notes.