Bryant was born to Luz Lebron and Oscar Bryant. He attended Thomas Jefferson High School. As a junior, he had 6 receptions for 62 yards. As a senior, he contributed to the team having a 10-2 record and reaching the FHSAA 6A playoffs. He registered 34 receptions for 756 yards and 11 touchdowns, while receiving All-Western Conference honors.
College career
Bryant accepted a football scholarship from Temple University. As a redshirt freshman, he became a starter at wide receiver in the third game against the University of Massachusetts Amherst. He set school records for freshman receptions and receiving yards. He was the team's second leading receiver behind Robby Anderson and also had 3 touchdowns. As a sophomore, he led the team with 54 receptions for 895 yards. He was second on the team with 4 receiving touchdowns. He also contributed to the team winning the American Athletic Conference title. He had 5 receptions for 94 yards against the University of Central Florida. He made 5 receptions for 115 yards against the University of South Florida. He had 9 receptions for 168 yards and one touchdown against Tulane University. He made 11 receptions for 151 yards against Wake Forest University in the 2016 Military Bowl. As a junior, he was fourth on the team with 29 receptions for 280 yards and no touchdowns. He had 7 receptions for 79 yards against Villanova University. As a senior, he led the team with 51 receptions for 690 yards. He was third on the team with 3 touchdowns. He had 7 receptions for 109 yards and 2 touchdowns against the University of Central Florida. He finished his college career as the school's all-time leading receiver with 173 receptions for 2,444 yards. He had 10 career receiving touchdowns.
After not being selected in the 2019 NFL draft, he received a tryout invitation for the Cincinnati Bengals rookie-minicamp, where he performed well enough to be signed as an undrafted free agent on May 11. He was waived on August 31, 2019.
On September 2, 2019, Bryant was signed to the Dallas Cowboys' practice squad. On October 2, he was promoted to the active roster to replace injured core special teams player Kavon Frazier. He has mainly been active on special teams and recorded his first two career special teams tackles in Week 7 against the Philadelphia Eagles. On Thanksgiving day, Bryant caught his first career pass for a 15 yard touchdown from Dak Prescott. Game announcer Jim Nantz jokingly iterated that the touchdown was caught by “Dez Bryant” but that was not the case. There is no known relation between the two.