The Church has had a long-standing interest in astronomy, due to the astronomical basis of the calendar by which holy days and Easter are determined. For instance, the Gregorian Calendar, promulgated in 1582 by Pope Gregory XIII, was developed by Aloysius Lilius and later modified by Christoph Clavius at the Collegio Romano from astronomical data. The Gregorian Tower was completed in 1580 for his purpose, designed by Bolognese architect Ottaviano Nonni. In the 18th century, the Papacy actively supported astronomy, establishing the Observatory of the Roman College in 1774. In 1789–1787, the Specola Vaticana in the Tower of the Winds within the Vatican was established under the direction of Msgr. Filippo Luigi Gilii. When Msgr. Gilii died, the Specola was closed down because it was inconvenient for students in the city because the dome of St. Peter's obstructed its view. Its instruments were transferred to the College Observatory. A third facility, the Observatory of the Capitol, was operated from 1827 to 1870. Father Angelo Secchi SJ relocated the College Observatory to the top of Sant'Ignazio di Loyola a Campo Marzio. In 1870, with the capture of Rome, the College Observatory fell into the hands of the Italian Government. Out of respect for his work, however, Father Secchi was permitted to continue using the Observatory. After Secchi's death in 1878 the Observatory was nationalized by the Italian government and renamed the Regio Osservatorio al Collegio Romano, ending astronomical research in the Vatican. In 1891, however, Pope Leo XIII issued a Motu Proprio re-founding the Specola Vaticana and a new observatory was built on the walls at the edge of the Vatican. The new Vatican Observatory remained there for the next forty years. In the late nineteenth-century the Vatican Observatory was part of a group of top astronomy institutions from around the world which worked together to create a photographic "Celestial Map" and an "astrographic" catalog pinpointing the stars' positions. Italian astronomer Father Francesco Denza led the Vatican's contribution to the project until his death in 1894. In the early twentieth-century Father John Hagen took over the project and recruited a group of nuns from the Sisters of the Holy Child Mary to work on the necessary recording and calculations. The sisters were Sisters Emilia Ponzoni, Regina Colombo, Concetta Finardi and Luigia Panceri.
By the 1930s, the smoke and sky-glow of the city had made it impossible to conduct useful observations in Rome. Pope Pius XI relocated the Observatory to Castel Gandolfo, which is southeast of Rome. By 1961, the same problems with light pollution made observing difficult at Castel Gandolfo. The Observatory then established the Vatican Observatory Research Group , with offices at the Steward Observatory of the University of Arizona in Tucson, Arizona. D.K.J. O'Connell produced the first color photographs of a green flash at sunset in 1960. In 1993, VORG completed construction of the Vatican Advanced Technology Telescope, which is at Mount Graham near Safford, Arizona. The Observatory's headquarters remain in Italy at Castel Gandolfo. In early 2008, the Vatican announced that the Observatory would be relocated to a former convent a mile away from the castle as part of a general reconstruction of the Papal residence. Its former space would be used to provide more room for the reception of diplomatic visitors. There was some commentary that the Observatory was being shut down or cut back, but in fact the Observatory staff welcomed the move. The old quarters in the castle were cramped and very poorly laid out for the Observatory's use. VORG research activities in Arizona continued unaffected.