Vange Leonel was born in São Paulo in 1963; great-granddaughter of General Ataliba Leonel, who fought in the 1932 Constitutionalist Revolution, and cousin of former Titãs member Nando Reis, her first musical ventures were with the post-punk band Nau, which was founded in 1985. Nau released an eponymous album by CBS in 1987, and also took part in the compilation Não São Paulo, Vol. 2, released by Baratos Afins; however, it would disband in 1989, after plans for a second studio album fell through, and Vange followed with a solo career. Her first solo album, Vange, was released in 1991 by Sony Music Entertainment, and spawned her most well-known song, "Noite Preta", which was used as the opening theme of the popular Brazilian telenovelaVamp. Another song off the album, "Esse Mundo", would be used as the opening theme for another telenovela, Perigosas Peruas. Her second solo release, the EPVermelho, came out in 1996 by the independent label Medusa Records, founded by Vange and her domestic partner, journalist Cilmara Bedaque, in the same year. Bedaque also co-authored numerous of Vange's songs since the times of Nau. Vermelho was not as well-regarded as her previous album though, and Vange abandoned the musical career to devote herself to literature. Vange came out as a lesbian in 1995, and since then began to milit toward the gay cause and women's rights. In 1999 she published her first book, Lésbicas, that was followed by Grrrls: Garotas Iradasin 2001; both were compilations of articles she wrote for now-defunct LGBT magazineSui Generis from 1997 to 2000. She also wrote for the Revista da Folha, CartaCapital and Mix Brasil, and alongside Cilmara Bedaque she also had a beer-related blog named "Lupulinas". In 2000, she wrote her first theatre play, As Sereias da Rive Gauche, that was performed in the same year under Regina Galdino's direction and published as a book in 2002. Her first and only novel, Balada para as Meninas Perdidas, was released in 2003. Her fifth and last literary work was the playJoana Evangelista, which came out in 2006; a modern-day reimagining of Joan of Arc's life, it deals with the theme of abortion. In a 2012 interview, Vange stated that she was working on a translation to Portuguese of Djuna Barnes' 1928 novel Ladies Almanack. Since then, however, no further announcements regarding the translation were given, and it is unknown if she got to finish the translation prior to her death.
Vange began a relationship with Cilmara Bedaque in 1986, and the couple registered their domestic partnership in 1995. It lasted until Vange's death in 2014.