Undecylprodigiosin
Undecylprodigiosin is an alkaloid produced by Streptomyces bacteria. It is one of the prodiginines pigments that is used for different medical uses including antimalarial activity.Biosynthesis
The biosynthesis of undecylprodigiosin starts with PCP apoprotein which is transformed into the holoprotein using acetyl CoA and PPtase then adenylation occurs utilizing L-proline and ATP. The resulting molecule is then oxidized by dehydrogenase enzyme. Elongation by decarboxylative condensation with malonyl CoA is followed by another decarboxylative condensation with L-serine using α-oxamine synthase domain. The compound is then cyclized, oxidized with dehydrogenase and methylated with SAM to give 4-Methoxy-2,2′-bipyrrole-5-carboxaldehyde intermediate which react with 2-undecylpyrrole to give undecylprodigiosin.
