UMP kinase


In enzymology, an UMP kinase is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are ATP and UMP, whereas its two products are ADP and UDP.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:UMP phosphotransferase. Other names in common use include uridylate kinase, UMPK, uridine monophosphate kinase, PyrH, UMP-kinase, and SmbA. This enzyme participates in pyrimidine metabolism.

Structural studies

As of March 2010, 19 structures have been solved for this class of enzymes, and are deposited in the PDB. All have a 3-layer architecture. These include accession codes,,, and.
Search for all UMP Kinases in the PDB using the at .