U.S. Route 52 in Ohio


U.S. Route 52 runs east–west across the southern part of the state of Ohio along the Ohio River, passing through or very near the cities and towns of Cincinnati, New Richmond, Point Pleasant, Moscow, Neville, Chilo, Rural, Utopia, Higginsport, Ripley, Aberdeen, Manchester, Wrightsville, Rome, Sandy Springs, Rockville, Friendship, Alexandria, Portsmouth, New Boston, Sciotoville, Sciotodale, Wheelersburg, Franklin Furnace, Hanging Rock, Ironton, Coal Grove, South Point, and Burlington.
For its first or so, the highway is overlapped with Interstate 74 and I-75 before it winds through downtown Cincinnati for several miles. The route is primarily two lanes between New Richmond and west of Portsmouth, where it becomes a four-lane partial access highway until it exits the state.

Major intersections