U.S. Route 45 in Kentucky U.S. Route 45 enters Kentucky at Fulton in Fulton County and travels northeast through Hickman County , Graves County , and McCracken County . After passing through Mayfield in Graves County it heads directly north into Paducah as a four-lane highway. In Paducah, US 45 serves as a major artery , intersecting with Interstate 24 at Exit 7, and intersecting US 60 and 62 . U.S. 45 leaves Kentucky from Paducah's northern border across the two-lane, metal-grate Brookport Bridge to Brookport, Illinois across the Ohio River .Route description US 45 enters Kentucky at Fulton in Fulton County where it travels around the west side and then north side of town before entering Hickman County. It travels just to the south and east of the Purchase Parkway as it passes briefly through Hickman County and into Graves County. In Graves County US 45 travels northeast and passes through the communities of Water Valley and Wingo . Roughly northeast of Wingo, US 45 passes through Mayfield where it forms an intersection with US 45 Bypass before passing through the heart of town. Just north of town, US 45 intersects US 45 Bypass and Purchase Parkway and becomes a four-lane divided highway as it turns toward the north . US 45 continues northward through rural sections of Graves County and into McCracken County. In McCracken County, US 45 passes through Lone Oak and then passes under I-24 as it enters Paducah. In Paducah, US 45 forms intersections with US 60, US 62 , US 60 Business, I-24 Business, and US 45 Business as it passes through the western part of town. US 45 crosses the Ohio River via the Brookport Bridge into Illinois from the Tennessee state line .History US 45 was signed in Kentucky by 1928, although it was not yet paved. The entire route in Kentucky was paved by 1939.Major intersections Special routes Mayfield bypass US 45 Bypass in Mayfield begins at a junction with US 45 on the southwest side of Mayfield and forms a concurrency with Purchase Parkway at Exit 21 north of US 45. It carries this concurrency for and ends at a junction with US 45 at Exit 25 of the parkway north of Mayfield. After the Purchase Parkway is re-designated as I-69, US 45 Bypass May be decommissioned.US 45 Business in Paducah begins at an intersection with US 45 in downtown Paducah and travels northeast through town. As it nears the Ohio River, it turns to the northwest and ends at a junction with US 45 south of the Brookport Bridge over the Ohio River from its origin.
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