U.S. Route 150 U.S. Route 150 is a 571-mile long northwest-southeast United States highway , signed as east-west. It runs from U.S. Route 6 outside of Moline, Illinois to U.S. Route 25 in Mount Vernon, Kentucky .Route description In the state of Illinois, U.S. 150 runs from the Quad City International Airport at U.S. Route 6 southeast to near Vermilion . U.S. 150 in Illinois is long. Between Moline and Danville , Route 150 closely parallels Interstate 74 .In the state of Indiana, U.S. 150 runs south with U.S. Route 41 from Terre Haute . It is then concurrent with its parent, U.S. Route 50 from Vincennes to Shoals . It then runs east to New Albany before overlapping Interstate 64 into Kentucky . Between Vincennes and New Albany the road follows the original route of the Buffalo Trace .Kentucky U.S. 150 runs concurrently with I-64 as it enters Kentucky from Indiana, crossing the Ohio River into Louisville on the Sherman Minton Bridge and exiting the I-64 freeway at North 22nd Street in the Portland neighborhood. From there, U.S. 150 runs south to West Broadway ; U.S. 150 follows Broadway across downtown to Baxter Avenue; after a brief run along Baxter, It then follows Bardstown Road , a major radial artery running southeasterly from downtown, with interchanges at Interstates 264 and 265 . Between West Main and West Broadway in Louisville, U.S. 150 is concurrent with U.S. Route 31W; from East Broadway and Baxter to Bardstown, Kentucky , it is concurrent with U.S. Route 31E. The route along Baxter Avenue and Bardstown Road follows the former Louisville and Bardstown Turnpike through the Highlands district of Louisville and past the historic Farmington plantation at the interchange with the Watterson Expressway. U.S. routes 150 and 31E separate at Bardstown near the Martha Layne Collins Blue Grass Parkway . U.S. 150 then continues southeast, around the city of Danville before terminating at Mount Vernon .History U.S. Route 168 was created in 1926 from Louisville to Mount Vernon, Kentucky, overlapping US 68 between Bardstown and Perryville . In 1934, US 150 absorbed US 168.Illinois Route 39 ran from Bloomington to Champaign on the current routing of U.S. 150.Major intersections Special routes U.S. Route 150 Business is a special U.S. Route in Springfield, Kentucky . The route runs through downtown Springfield while US 150 bypasses the town to the northeast. It intersects Kentucky state highways 152 , 555 , 528 , 1584 , and 1404 .Danville bypass U.S. Route 150 Bypass is a special U.S. Route in Danville, Kentucky . The route bypasses Danville to the southwest while US 150 runs through downtown. The route is overlapped by US 127 Byp. for approximately the first half of its length. It intersects US 127, along with Kentucky state routes 34 and 37 .
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