U.S. Route 11 enters the state of Mississippi along Interstate 59. After a short distance, US 11 and Interstate 59 interchange at Exit 1 with Mississippi Highway 607, where 607 ends and U.S. Route 11 takes over its northeastern alignment. US 11 heads to the northeast in the community of Nicholson, where it parallels the Norfolk Southern railroad tracks. The highway progresses northward along with the railroad tracks. The three are connected soon after at an intersection with Section Line Road, which runs westbound from US 11. Several miles north of the interchange from Interstate 59, I-59 begins to parallel once again to the far east. After a while, US 11 intersects with South Haugh Avenue. US 11 continues northward where the highway enters the city ofPicayune. A short distance into Picayune, US 11 intersects with a divided highway segment of Mississippi Highway 43. US 11 and the railroad tracks continue to the north and intersects with West and East Canal Streets in the center of Picayune. After the intersection with East 4th Street, US 11 continues northeastward. After a short distance, US 11 intersects with East Sycamore Road, an alignment of Mississippi Route 43. North of Route 43, the highway continues northward, entering the community of Richardson. US 11 continues northward into the community of Ozona, paralleling an original alignment, which is signed to the east. After the intersection the US 11 heads towards the community of Carriere. US 11 soon afterwards enters the community of Hawthorne. The US 11 then enters the community of McNeill. After McNeill, US 11 turns to the northeast once again. US 11 passes through the communities of Tyler and Millard. US 11 heads to the east and enters the community of Derby. There, US 11 turns to the northeast, intersecting with Mississippi Highway 26. After that intersection, US 11 continues northward into Poplarville. In Poplarville, the highway intersects with a short, original alignment of itself. As the highway continues northward, it begins to parallel Interstate 59 once again. After a short distance, US 11 leaves Pearl River County for Lamar County. After the county crossing, Red Top Road merges in, and the route begins paralleling the nearby railroad tracks. After a short distance, US 11 enters the city of Lumberton.
Lamar County
US 11 enters the city of Lumberton once crossing the county line then heads to the local community of Seneca. The highway continues to the northeast, entering the community of Talowah and passes through the city of Purvis. Paralleling the original alignment, the two roads eventually intersect and switch directions, eventually it will intersect with Mississippi Highway 589, which becomes concurrent. US 11 enters the community of Richburg before crossing the county line and into Forrest County.
Forrest County
In the community of Richburg, US 11 crosses the county line from Lamar County and into Forrest County. The highway interchanges with Exit 60 on Interstate 59 and U.S. Route 98 then enters the community of Bonhome. At an intersection with Richburg Road, US 11 leaves Bonhome, and enters the large city of Hattiesburg. In Hattiesburg, US 11 makes a curve to the north and changes to Broadway. US 11 becomes a divided highway and reaches an interchange with U.S. Route 49 at a complete cloverleaf interchange. After the interchange ends, US 11 continues to the north, and after the intersection with 64th Street, US 11 enters the city with commercial buildings surrounding the highway. In the city, US 11 parallels some nearby railroad tracks. US 11 comes back together and continues to the north and intersects with Mississippi Highway 42, which becomes concurrent. Routes 11 and 42 continues to the northeast to Hattiesburg. Routes 11 and 42 fork, with 11 heading to the north and 42 heading to the east. Eventually, US 11 enters Petal paralleling the nearby railroad tracks, the US 11 becomes less developed and leaves Petal. US 11 continues northward and comes to the community of Dragon. The route leaves Dragon and begins a slight curve to the northwest, still paralleling the railroad tracks. At an intersection near Eastabutchie, US 11 crosses the county line and into Jones County.
