He was named an Assistant Professor at MIT in 1992 and Associate Professor with tenure in 1997. In 2000, he was promoted to full Professor standing. He has taught the spring version of at MIT with Professor Hazel Sive and currently teaches The Hallmarks of Cancer at MIT with Professor Matthew Vander Heiden. He served on the Board of Scientific Advisors of the National Cancer Institute and is a past president of the American Association for Cancer Research. He also sits on the board of directors at Thermo Fisher Scientific, Inc. and Aveo Pharmaceuticals Inc. He is a member of the Scientific Advisory Board at T2Biosystems, Inc. and at Epizyme, Inc.
Research
He has pioneered the use of gene-targeting technology in mice to study cancer-associated genes and to construct mouse models of many human cancer types. The Jacks lab studies the genetic events that lead to the development of cancer. The lab focuses on using a series of mouse strains carrying engineered mutations known to be involved in human cancer. Through loss-of-function and gain-of-function mutations in tumor suppressor genes as well as the K-ras oncogene, mouse models of many types of cancer have been constructed, including pancreatic cancer, astrocytoma, endometrioid ovarian cancer, colorectal cancer, sarcoma, retinoblastoma, and tumors of the peripheral nervous system.
Jacks has been confirmed as a keynote speaker for the biotechnetworkingconference 'Leading Biotech'. The event took place April 24, 2019 in Boston MA.
Publications
Kumar MS, Lu j, Mercer KL, Golub, TR and Jacks T. 2007. Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nature Genetics, 39:673-677
Shaw AT, Meissner A, Dowdle JA, Crowley D, Magendantz M, Ouyang C, Parisi T, Rajagopal J, Blank LJ, Bronson RT, Stone JR, Tuveson DA, Jaenisch, R, and Jacks, T. 2007. Sprouty-2 Regulates Oncogenic K-ras in Lung Development and Tumorigenesis. Genes & Development, 21:694-707.
McLaughlin ME, Kruger GM, Slocum KL, Crowley D, Michaud NA, Huang J, Magendantz M, and Jacks T. 2007. The Nf2 tumor suppressor regulates cell-cell adhesion during tissue fusion. PNAS,104:3261-3266.
Ventura, A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, Newman J, Reczek EE, Weissleder R and Jacks T. 2007. Restoration of p53 function leads to tumor regression in vivo. Nature, 445, 661-665
Macpherson D, Conkrite K, Tam M, Mukai S, Mu D, and Jacks T. 2007. Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification. EMBO J, 26, 784-794
Carla F. Kim, Erica L Jackson, Amber E Woolfenden, Sharon Lawrence, Imran Babar, Sinae Vogel, Denise Crowley, Roderick T Bronson, Tyler Jacks 2005. Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell, 121:823-835.
Alejandro Sweet-Cordero, Sayan Mukherjee, Aravind Subramanian, Han You, Jeff Roix, Christine Ladd, Todd R. Golub, Tyler Jacks. 2005. An oncogenic Kras expression signature identified by cross-species gene expression analysis. Nature Genetics, 37, 48-55
Daniela M. Dinulescu, Tan A. Ince, Bradley J. Quade, Sarah A. Shafer, Denise Crowley, Tyler Jacks. 2005. Role of K-ras and Pten in the Development of Mouse Models of Endometriosis and Endometrioid Ovarian Cancer. Nature Medicine, 11, 63–70.
Kenneth P. Olive, David A. Tuveson, Zachary C. Ruhe, Bob Yin, Nicholas A. Willis, Roderick T. Bronson, Denise Crowley, Tyler Jacks. 2004. Mutant p53 Gain-of-Function in Two Mouse Models of Li-Fraumeni Syndrome. Cell, 119, 847–860.
Ventura A, Meissner A, Dillon CP, McManus M, Sharp PA, Van Parijs L, Jaenisch R, Jacks T. 2004. Cre-lox-regulated conditional RNA interference from transgenes. PNAS :10380-10385.
