Tripartite motif family

Function

Structure

• a RING finger domain
• one or two B-box zinc finger domains
• * when only one B-box is present, it is always a type-2 B-box
• * when two B-boxes are present the type-1 B-Box always precedes the type-2 B-Box
• coiled coil region

• Group 1 proteins: a C-terminal domain selected from the following list:
• * NHL and IGFLMN domains, either in association or alone
• * PHD domain associated with a bromodomain
• * MATH domain
• * ARF domain
• * EXOIII domain or
• Group 2 proteins: a SPRY C-terminal domain
• *e.g. TRIM21

  Family members

• Group 1 members possess a variety of C-terminal domains, and are represented in both vertebrate and invertebrates
• Group 2 is absent in invertebrates, possess a C-terminal SPRY domain

• Group 1
• * PHD-BROMO domain containing: TRIM24, TRIM28, TRIM33 – act as corepressors
• * 1-10: TRIM1, TRIM2, TRIM3, TRIM8, TRIM9
• * 11-20: TRIM12, TRIM13, TRIM14, TRIM16, TRIM18, TRIM19
• * 21-30: TRIM23, TRIM25, TRIM29, TRIM30
• * 31-40: TRIM32, TRIM36, TRIM37
• * 41-50: TRIM42, TRIM44, TRIM45, TRIM46, TRIM47
• * 51-60: TRIM51, TRIM53, TRIM54, TRIM55, TRIM56, TRIM57, TRIM59
• * 61-70: TRIM62, TRIM63, TRIM65, TRIM66, TRIM67, TRIM69, TRIM70
• * 71-75: TRIM71
• Group 2
• * 1-10: TRIM4, TRIM5, TRIM6, TRIM7, TRIM10
• * 11-20: TRIM11, TRIM12, TRIM15, TRIM17, TRIM20
• * 21-30: TRIM21, TRIM22, TRIM26, TRIM27, TRIM30
• * 31-40: TRIM31, TRIM34, TRIM35, TRIM38, TRIM39, TRIM40
• * 41-50: TRIM41, TRIM43, TRIM48, TRIM49, TRIM50
• * 51-60: TRIM51, TRIM52, TRIM53, TRIM57, TRIM58, TRIM60
• * 61-70: TRIM61, TRIM64, TRIM68, TRIM69, TRIM70
• * 71-75: TRIM72, TRIM73, TRIM74, TRIM75