Most trekkers cross the pass from east to west, which is the easiest and safest direction. It is not possible to cross Thorong La from Manang to Muktinath in one day. Trekkers usually spend the first night in Yak Kharka and second night in Thorong Phedi — which is situated at, or at Thorong High Camp — which is situated at before attempting to go over Thorong La Pass. Choosing this option decreases the elevation gain and loss for that day's hike, as well as decreasing the distance. The staff of the Himalayan Rescue Association post in Manang recommend that trekkers spend five nights between their arrival in Manang and the crossing to Muktinath. The additional time spent in Manang allows trekkers to acclimatize sufficiently to minimize the risk of acute mountain sickness. The Himalayan Rescue Association operates a medical clinic at Manang, and a small satellite medical clinic at Thorong Phedi. The route from west to east is much more difficult, because it does not allow most trekkers sufficient time for acclimatization to the altitude. For trekkers choosing this direction of travel, the last place where it is possible to spend the night is located at Ranipauwa, where there is a lodge situated at. There is also a very basic lodge located at Muktinath Phedi, situated at, but this lodge is only open seasonally. Trekkers going from west to east must therefore ascend at least and descend at least in one day. The safest months to cross the pass are March–April and October–November. Attempting to cross Thorong La Pass at other times of the year is dangerous due to the increased risk of avalanches, frostbite and the likelihood of a storm or a whiteout, which can cause trekkers to become disoriented and lost. Trekkers usually depart Thorung Pedi / Thorung High camp a few hours before sunrise, as strong winds typically begin a few hours after sunrise.
Local climate
The local climate on the western side of the pass is much drier than on the eastern side. There is practically no vegetation on the western side, except where irrigated, while in the Manang valley there is much more vegetation and cultivation is possible, while it is still fairly dry, as the valley is protected from the wet southern monsoon winds by the Annapurna mountain range.
