The narrative starts with Therese, sexually precocious in spite of herself, from solid bourgeois stock, being placed by her mother in a convent when she is 11 years old. There she eventually becomes sick because her pleasure principle is not permitted to express itself, putting her body into disorder, and bringing her close to the grave until her mother finally yanks her out of the convent at age 23. She then becomes a student of Father Dirrag, a Jesuit who secretly teaches materialism. Therese spies on Dirrag counseling her fellow student, Mlle. Eradice, and preying on her spiritual ambition in order to seduce her. Through flagellation and penetration, Dirrag gives Mlle. Eradice what she thinks is spiritual ecstasy but is actually sexual. "Father Dirrag" and "Mlle. Eradice" are named after anagrams of Catherine Cadière and Jean-Baptiste Girard, who were involved in a highly publicized trial for the illicit relationship between priest and student in 1730. After that she spends time with Mme. C and the Abbé T., and spies on them on multiple occasions, while they discuss libertine political and religious philosophy just before they engage in, and sometimes during, various acts of sex. Therese's sexual education continues with her relationship with Mme. Bois-Laurier, an experienced prostitute, who is also a virgin much to her clients' surprise, delight and also disappointment. Many a John will try to break through her maidenhead, without success. This section of the novel constitutes an arguably hilarious variation on the whore dialogues that were common in early pornographic novels. Finally, Therese meets the unnamed Count who wants her for his mistress. She refuses him intercourse, out of her fear of death in childbirth and also because she finds masturbation to be sufficiently pleasurable in and of itself. He makes a bet with her. If she can last two weeks in a room full of erotic books and paintings without masturbating, he will not demand intercourse with her. Therese loses and becomes the Count's permanent mistress.
Philosophical and social concepts
For all of its printed debauchery, the work has some philosophical merit in its underlying concepts. Between the more graphically adult sections of the novel, philosophical issues would be discussed amongst the characters, including materialism, hedonism and atheism. All phenomena are matter in motion, and religion is a fraud, though useful for keeping the working classes in line. The book not only draws attention to the sexual repression of women at the time of the enlightenment, but also to the exploitation of religious authority through salacious acts.
Influence and adaptations
Dostoievsky referred repeatedly to the novel in his working notes for both The Idiot and The Possessed.
Thérése Philosophe was loosely adapted as the second segment of Walerian Borowczyk's French anthology filmImmoral Tales. Therese was played by Charlotte Alexandra.