Tachykinin receptor 3 Tachykinin receptor 3TACR3 , is a protein which in humans is encoded by the TACR3 gene .Function This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence . The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B .A number of selective ligands are available for NK3 . NK3 receptor antagonists are being investigated as treatments for various indications .Agonists Neurokinin B – endogenous peptide ligand , also interacts with other neurokinin receptors but has highest affinity for NK3 Senktide – 7-amino acid polypeptide , NK3 selective, CAS# 106128-89-6Antagonists Fezolinetant Osanetant Pavinetant Talnetant SB-222,200 – potent and selective antagonist , Ki = 4.4 nM , 3-Methyl-2-phenyl-N--4-quinolinecarboxamide, CAS# 174635-69-9 SB-218,795 – more selective than SB-222,200, Ki = 13 nM, --methyl ester benzeneacetic acid , CAS# 174635-53-1
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