He was born in Acholiland, then a region of southern Sudan under British rule. After graduation from secondary school in Uganda, he attended the National Teachers College in Kampala, Uganda’s capital, before continuing his undergraduate studies at Knoxville College in Tennessee, and postgraduate studies at Howard University. At the University of Iowa Writer's Workshop, he was the first African graduate in 1968. On the completion of his studies in the US, the tyrannical regime of Idi Amin prevented him from returning to Uganda. Instead, he went to neighbouring Kenya and taught at the University of Nairobi. Furthermore, he has also taught at universities in Sudan, SouthSudan, Papua New Guinea, Australia, Japan, and South Africa. In collaboration with Henry Owuor-Anyumba and Kenyan writer Ngugi wa Thiong'o, he wrote On the Abolition of the English Department in 1972. Based on this article, which inspired postcolonial students of English in Africa to question the practices of their discipline, Liyong, Owuor-Anyumba and wa Thiong'o were criticised for advocating cultural or even racial purity within academia. Rather, they sought to re-establish traditional East African ways of knowledge and understanding in literature, in an effort towards authenticity and as a means for the region to better understand itself in the context of national independence. By placing African culture at the centre of education, "all other things be considered in their relevance to situation, and their contribution towards understanding ". This philosophy was also politically significant at a time when East African governing bodies were struggling against the influence of post-colonial powers, such as the US and Great Britain. In February 2020, Lo Liyong was suspended from his teaching assignment by the University of Juba, because he had written critical comments on South Sudan’s government in a local South Sudanese newspaper. In a letter to Professor John A. Akec, Vice Chancellor of the University of Juba, 28 US-based academics, including a number of South Sudanese alumni of the University of Juba, expressed their opposition to the suspension. According to the Encyclopaedia Britannica, "Liyong wrote highly imaginative short narratives, such as Fixions, and unorthodox free verse, His nonfiction output consists of argumentative and amusing personal essays and bold literary criticism, presenting challenging new ideas in an original manner." Liyong has published over twenty books, including Carrying Knowledge Up a Palm Tree, an anthology of poetry that addresses various contemporary issues and follows African progress in recent history. The East African Literature Bureau published many of Liyong's earlier works in English, as well as in translation into East African languages.
