Syrian elephants were among the largest Asian elephant subspecies to have survived into historic times, measuring or more at the shoulder; on par with the largest reported Indian elephants. Skeletal remains show it did not differ much from the Indian subspecies, except in size. A study of mitochondrial DNA from 3500 year old remains from Gavur Lake Swamp southwest of Kahramanmaraş in Turkey, which represent an apparently wild population, found that they were within extant genetic variation and belonged to the β1 subclade of the major β clade of Asian Elephants, β1 being the predominant clade among Indian elephants. They carried an extremely rare mitochondrial haplotype only previously found in a single modern elephant in Thailand, the origin of the haplotype was placed between 3,700–58,700 years ago with a mean estimate of 23,500 years ago, suggesting that the population did not descend from Middle PleistoceneElephas fossils known from the region and if it was natural it must have arrived in the region as an expansion from the core range of the Asian elephant during the Late Pleistocene or Holocene. The data was inconclusive as to whether the population had a natural or anthropogenic origin.
No remains of Elephas are known from the Middle East after 200,000 years ago until 3,500 years ago. This long hiatus makes some scholars suspect that the Asian Elephants were artificial introductions to the Middle East, possibly from India, though this is difficult to prove. The extinction date is suggested to be around 700 BC, based on osteoarchaeological and historical evidence. This was possibly due to climactic shifts and changing land use during the early Iron Age Syrian elephants are frequently mentioned in Hellenistic history; the Seleucid kings, who maintained numerous war elephants, reigned in Syria during that period. These elephants are believed to be Indian elephants, which had been acquired by the Seleucid kings during their eastern expansions. Or they are believed to be population of Indian elephants in Middle East. It is attested by ancient sources such as Strabo and Polybius that Seleucid kings Seleucus I Nicator and Antiochus III the Great had large numbers of imported Indian elephants. Whether these "Indian elephants" were imported due to scarcity of native Syrian elephants or due to their accomplished training and domestication as war elephants remains unclear. Hannibal had a war elephant known as "Surus"; it has been suggested to mean "the Syrian". It was said by Cato to have been his best elephant. In that case, the elephant may have been of Seleucid stock. If it were in fact of native Syrian stock, or an imported Indian elephant, remains subject to speculation.