Firestein was raised in Philadelphia. As a child, Firestein had many interests. In an interview with a reporter for Columbia College, he described his early history. "I started out with the usual childhood things — cowboy, fireman. My first interests were in science. I wanted to be an astronomer." Firestein attended an all-boys middle school, a possible reason he became interested in theater arts, because they were able to interact with an all-girls school. Firestein worked in theater for almost 20 years in San Francisco and Los Angeles and rep companies on the East Coast. At the age of 30, Firestein enrolled in San Francisco State as a full-time student. He has credited an animal communication class with Professor Hal Markowitz as "the most important thing that happened to me in life." Firestein received his graduate degree at age 40.
Career
After earning his Ph.D. in neurobiology, Firestein was a researcher at Yale Medical School, then joined Columbia University in 1993. At the Columbia University Department of Biological Sciences, Firestein is now studying the sense of smell. In his neuroscience lab, they investigate how the brain works, using the nose as a "model system" to understand the smaller piece of a difficult complex brain.
''Ignorance: How It Drives Science''
In his 2012 book Ignorance: How It Drives Science, Firestein argues that pursuing research based on what we don't know is more valuable than building on what we do know. When asked why he wrote the book, Firestein replied, "I came to the realization at some point several years ago that these kids must actually think we know all there is to know about neuroscience. And that's the difference. That's not what we think in the lab. What we think in the lab is, we don't know bupkis. So I thought, well, we should be talking about what we don't know, not what we know." The book was largely based on his class on ignorance, where each week he invited a professor from the hard sciences to lecture for two hours on what they do not know. No audio-visuals and no prepared lectures were allowed, the lectures became free-flowing conversations that students participated in. Firestein explained to talk show hostDiane Rehm that most people believe ignorance precedes knowledge, but in science, ignorance follows knowledge. Knowledge enables scientists to propose and pursue interesting questions about data that sometimes don't exist or fully make sense yet. "I use that term purposely to be a little provocative. But I don't mean stupidity. I don't mean dumb. I don't mean a callow indifference to facts or data or any of that," Firestein said. Instead, thoughtful ignorance looks at gaps in a community's understanding and seeks to resolve them.
Scientific method
The scientific method is a huge mistake, according to Firestein. He says that a hypothesis should be made after collecting data, not before. Firestein claims that scientists fall in love with their own ideas to the point that their own biases start dictating the way they look at the data. Oddly, he feels that facts are sometimes the most unreliable part of research. He feels that scientists don't know all the facts perfectly, and they "don't know them forever."
According to Firestein, scientific research is like trying to find a black cat in a dark room: It's very hard to find it, "especially when there's no black cat." His thesis is that the field of science has many black rooms where scientists freely move from one to another once the lights are turned on. Another analogy he uses is that scientific research is like a puzzle without a guaranteed solution.
