Sodium-hydrogen antiporter 3 regulator 1
Sodium-hydrogen antiporter 3 regulator 1 is a regulator of Sodium-hydrogen antiporter 3. It is encoded by the gene SLC9A3R1. It is also known as ERM Binding Protein 50 or Na+/H+ Exchanger Regulatory Factor. It is believed to interact via long-range allostery, involving significant protein dynamics.Mechanism
Members of the ezrin -radixin -moesin protein family are highly concentrated in the apical aspect of polarized epithelial cells. These cells are studded with microvilli containing bundles of actin filaments, which must attach to the membrane to assemble and maintain the microvilli. The ERM proteins, together with merlin, the NF2 gene product, are thought to be linkers between integral membrane and cytoskeletal proteins, and they bind directly to actin in vitro. Actin cytoskeleton reorganization requires the activation of a sodium/hydrogen exchanger. SLC9A3R1 is an ERM-binding protein.Interactions
Sodium-hydrogen antiporter 3 regulator 1 has been shown to interact with:
- ADRB2,
- Beta-catenin,
- CFTR,
- GNAQ,
- OPRK1,
- PAG1,
- PDGFRA,
- PDGFRB,
- PDZK1,
- PTH1R,
- SLC4A8,
- YAP1, and
- EZR
