While Parker was not drafted out of college, the Cleveland Cavaliers signed him for the 2002–03 season. In 2003, Parker signed with Aris Thessaloniki of the Greek League and helped the team win the 2004 Greek Basketball Cup in the final against Olympiacos. He returned to the NBA in 2004 and played for the Detroit Pistons and the Phoenix Suns. He then signed a contract with the Los Angeles Lakers during the summer of 2005. Not well-known entering the 2005 season, Parker gained recognition as the starting point guard for the Lakers under coach Phil Jackson. While many experts thought that either newly-signed veteran Aaron McKie or Sasha Vujačić would start at point guard, Parker became the surprise starter in the Lakers' season opener against the Denver Nuggets and went on to score at least 20 points in four of his first five games. This impressed Jackson, and Parker found himself in the starting line-up for the Lakers. From 2005 until 2007, Parker started 162 straight games, averaging 11.5 points. During the last two games of the regular season and the playoffs, Parker lost his starting spot to rookie Jordan Farmar. While with the Lakers, Parker clashed with coaches and players. He admitted to intentionally ignoring teammate Kobe Bryant and not passing him the ball. Bryant singled out Parker as a bad teammate, saying in 2012 that Parker "shouldn't have been in the NBA, but were too cheap to pay for a point guard." On July 26, 2007, Parker signed with the Miami Heat. For the Heat, Parker wore jersey number 21. His production dropped off dramatically while with the Heat, with averages of 4.8 points, 1.7 assists and 2.1 rebounds, compared to his 11.1 in 164 games with the Los Angeles Lakers. After a physical altercation that Parker had with a parking attendant in November 2007, the Miami Heat put him on paid leave to investigate the matter. On March 10, 2008, the Miami Heat officially waived Parker. The Los Angeles Clippers then signed him for the rest of the season on March 12, 2008. On July 10, 2008, the Los Angeles Clippers officially renounced their rights to Parker. In the 2008 offseason, Parker was signed by the Denver Nuggets but was released on October 23, 2008, as the Nuggets trimmed their roster to the league-allowed 15. He then played with the Rio Grande Valley Vipers of the NBA Development League. On January 9, 2009, Parker officially signed with Guangdong Southern Tigers of the Chinese Basketball Association. In September 2010, he signed a one-year contract with the Russian club Spartak Saint Petersburg. In January 2011, he returned to Greece and signed a contract with Iraklis Thessaloniki. In January 2012, Parker signed with Petrochimi Bandar Imam of the Iranian Basketball Super League. He later played in Venezuela, then signed with the Indios de San Francisco de Macorís of the Dominican Republic. In December 2012, Parker signed with Cibona Zagreb of the Adriatic Basketball Association. After only 5 games in Adriatic League, Parker was released. In March 2013, he returned to Greece and signed a contract with Peristeri of the Greek League. In January 2014, he signed with his former team Guaros de Lara. He left the team that March. In June, Parker played in The Basketball Tournament. His team reached the semi-finals, and Parker's averages for the tournament were 16.2 points, 7.8 rebounds, 7.0 assists and 1.8 steals per game. In February 2015, Parker signed with Mon-Altius Madimos Falcons of the Mongolian National Basketball Association. He averaged 24 points, 7.0 rebounds, 6.5 assists and 4.1 steals per game. On November 30, 2017, Parker signed with the Albany Patroons of the North American Premier Basketball.
NBA career statistics
Regular season
Playoffs
Personal life
Parker earned his nickname "Smush" at the age of 13. According to childhood friends, he often fouled out during pickup games by "smushing" opponents' faces as retribution for stealing the ball away from him. Parker has one daughter.