One of six children, Sefora Hixsonia Ntombela was born in the small farming town of Tweeling in the Free State. She was given the nickname of "Sisi" at a young age. She attended the Tweeling Combine School and matriculated from Kganyeng Secondary School. She went on to study at Bonamelo Training College and returned to the Tweeling Combine School as a teacher. Due to Apartheid and the tense political situation at the time, she secretly taught her pupils about Nelson Mandela. One of the pupils was the school principal's child and reported her for the secret lessons. She left the teaching profession due to the matter.
Political career
Ntombela worked for the Department of Health as a family planner and youth consultant. Later on, Ntombela became a member of the African National Congress and was elected the chairperson of the Tweeling African National Congress Women's League branch. She soon became Regional Chairperson. Following the 1994 elections, Ntombela was elected mayor of the Tweeling municipality and served in the position until her election to the Free State Provincial Legislature in 1999. She remained in the legislature until she was appointed to the National Assembly in 2001. She returned to the provincial legislature in 2004 and was named as Chairperson of both the Social Development and Health Portfolio Committees. In May 2009, newly-elected Free State PremierAce Magashule announced that Ntombela would take up the post of MEC for Social Development. Ntombela was elected Deputy President of the African National CongressWomen's League in August 2015. Magashule reshuffled his Executive Council in October 2016 and appointed Ntombela to the Cooperative Governance and Traditional Affairs and Human Settlements portfolio of the Executive Council. In March 2018, Ntombela was selected by the African National Congress to succeed Ace Magashule as Premier of the Free State. She took office on 27 March 2018 and became the fourth female Premier of the province. She was elected Treasurer of the Free State ANC branch in May 2018. Following the May 2019 elections, the African National Congress announced that it had retained Ntombela in her position as Premier of the Free State. She is now serving a full term that commenced on 22 May 2019.