He was the son and heir of Anthony Smithson of Newsham anciently "Newsham Broghton Lith", in the Parish of Kirkby Ravensworth, North Riding of Yorkshire, by his wife Eleanor Catterick, daughter and heir of George Catterick of Stanwick.
As a further token of the king's gratitude, in order to distinguish him from the rest of his family, he was granted the honour of a different coat of arms: Or, on a chief embattled azure three suns proper.
Tottenham Cross in Middlesex. The site of his mansion is thought to be where stands today a terrace of houses called Northumberland Terrace, built by Robert Plimpton in 1752 "built on land where previously stood some medieval mansions, one of which was called Percy House". The magnificent baroque gate piers and railings of Percy House survive.
Estates in Suffolk.
Marriage and children
He married Dorothy Rawstorne , daughter of Jerom Rawstorne of Plaistow in Essex. The will proved on 22 Nov. 1658 of "Jeramy Rawstorne" of London, a member of the Worshipful Company of Merchant Taylors survives in the Lancashire Archives summarised as follows: By his wife he had four sons and two daughters, of which only three survived him:
Sir Jerome Smithson, 2nd Baronet, eldest son and heir, married Mary Wingate, daughter and heiress of Edward Wingate of Lockley's Hall in Hertfordshire, MP for St Albans 1640-42.
Hugh Smithson, 2nd son, who inherited his father's Suffolk estates, a haberdasher of Old Exchange Precincts in the City of London, who married Mrs Alice Yeane, by whom he had one daughter Anne Smithson, married to Sir Henry Johnson of Bradenham in Buckinghamshire, Blackwall in Middlesex and Friston in Suffolk, several times MP for Aldeburgh in Suffolk, 'the greatest shipbuilder and shipowner of his day', who had by her an only daughter Anne Johnson, the wife of Thomas Wentworth, 1st Earl of Strafford, KG, First Lord of the Admiralty.
Anthony Smithson, 3rd son, a barrister at Gray’s Inn who inherited his father's estates at Tottenham Cross in Middlesex and at Armin in Yorkshire. He married Susanna Barkham, daughter of Sir Edward Barkham, 1st Baronet, MP, of South Acre in Norfolk, by whom he had one son Hugh Smithson of Tottenham in Middlesex, several times MP for Middlesex, who inherited estates worth £3,000 p.a. in Middlesex and Yorkshire. He married firstly Hester Godfrey, daughter of Michael Godfrey of Woodford in Essex, by whom he had 7 children who all died unmarried. He married secondly Constantia Hare, only daughter of Henry Hare, 2nd Baron Coleraine, without children. His heir was his cousin Sir Hugh Smithson, 4th Baronet, later 1st Duke of Northumberland.
Death and burial
He died on 21 October 1670, aged 72, at his home at Tottenham High Cross, Middlesex, and was buried in his parish church of St John the Baptist, Stanwick St John, where survives his elaborate monument showing two effigies, of himself and his wife, probably sculpted by William Stanton of London. It displays the following inscription: