The nomenSeius is derived from the name of Seia, the goddess of sowing. Chase classifies it among those gentilicia that either originated at Rome, or cannot be shown to have come from anywhere else.
Marcus Seius L. f., a friend of Cicero, who despite having been heavily fined early in his career, spent lavishly as curule aedile. He was the accuser of Marcus Saufeius, whom Cicero defended on the charge that he had participated in the murder of Publius Clodius Pulcher.
Quintus Seius Postumus, an eques, whose house Publius Clodius Pulcher coveted. Seius refused Clodius' offer, and according to Cicero, was poisoned by Clodius as a result.
Seius, one of the partisans of Marcus Antonius, whom Cicero harangues in his Philippics.
Gnaeus Seius, the first owner of the infamous horse Sejanus, a greatly-admired beast who supposedly brought doom to all who possessed him, giving rise to the proverb, ille homo habet equum Sejanum, said of those suffering ill fortune.
Lucius Seius L. f. M. n. Tubero, the brother or half-brother of Sejanus, was appointed consul suffectus in AD 18, in the place of Tiberius. He served alongside Germanicus, whose legate he had been during his campaign in Germania. In 24, he was falsely accused of majestas, impugning the emperor's dignity. He might be the same Lucius Seius who was proconsul of Sicily.
Lucius Seius L. f. M. n., better known as Lucius Aelius Sejanus, praetorian prefect under Tiberius, gained the emperor's trust and became his closest advisor, exploiting rivalries within the imperial household to his own benefit, and maneuvering himself into a position to succeed to the empire. His schemes were revealed, and he was condemned and put to death during his own consulship, in AD 31.
Seius Quadratus, implicated as one of the associates of Sejanus, following the latter's downfall.
Lucius Seius Quadratus, perhaps the associate of Sejanus, was one of the Seviri Augustales, according to an inscription dating to the first half of the first century AD.
Marcus Seius Varanus, consul suffectus in AD 41, holding office for the months of September and October.
Gaius Seius M. f. Calpurnius Quadratus Sittianus, perhaps a descendant of the Seius Quadratus who was implicated in the schemes of Sejanus, was tribune of the plebs, quaestor, praetorperegrinus, and governor of Gallia Narbonensis.
Publius Seius Fuscianus, consul suffectus about AD 151, was a close friend of Marcus Aurelius, whom he had known since childhood. Fuscianus was praefectus urbi from 187 to 189, and consul ordinarius in 188.
Seius Superstes, curator operum locorumque publicorum, caretaker of public buildings, in AD 193.
Seia M. f. Gaetula, the wife of Marcus Naevius Censitus, mother of Naevia Marciana, Naevia Naevilla, and Marcus Naevius Sejanus, and grandmother of Sabinia Celsina, was buried at Cirta in Numidia.
Seius P. n. Carus, the grandson of Fuscianus, was put to death by Elagabalus in AD 219, allegedly for plotting a revolt among the soldiers, but in fact because of his wealth and influence.
Seia P. n. Fuscinilla, the sister of Seius Carus, named on a lead pipe discovered at Rome.
Lucius Seius Herennius Sallustius, an esteemed nobleman in the time of Severus Alexander, who married Sallustius' daughter. Sallustius sought the protection of the Praetorian Guard against the abuse of Julia Mamaea, the emperor's mother, who cruelly treated her daughter-in-law; accusing him of treason, Julia had him put to death.
Gnaea Seia L. f. Herennia Sallustia Barbia Orbiana, one of the wives of Severus Alexander, and Roman empress for about two years before her father's downfall, after which she was divorced and exiled to Libya.