After working with Gerald Edelman and Giulio Tononi during his postdoctoral work in San Diego and Wisconsin, Hill joined the Computational Biology group at the IBMThomas J. Watson Research Center. There he served as Project Manager for Computational Neuroscience on the Blue Brain Project from 2006-2008. He subsequently joined the EPFL Blue Brain team. Hill served as the Executive Director of the International Neuroinformatics Coordinating Facility from 2011-2013 and as its Scientific Director from 2013-2016. He developed the corestrategy and design of the neuroinformatics infrastructure of the EU Human Brain Project, led its development during its start-up phase, and in 2014 was co-director of the project. As of September, 2017, Hill has been named inaugural Director of the Krembil Centre for Neuroinformatics at the Centre for Addiction and Mental Health in Toronto, Canada. The center will apply machine learning and artificial intelligence techniques, as well as multi scale modeling of the brain to the understanding of mental health disorders Prior to this, Hill served as co-Director of Blue Brain, where he led the Neuroinformatics Division of Blue Brain. In this role, he directed the development of Blue Brain Nexus, an open-source data integration, search and tracking platform adopted by both the Blue Brain Project and Human Brain Project. Hill has developed a number of large-scale brain models and simulations, including the first large-scale model of the visual thalamocortical system of the cat which accurately replicates multi-scale electrophysiological phenomena during wakefulness and sleep. He has also co-led the Blue Brain's efforts to create digital reconstructions of neocortical microcircuitry. He serves on the advisory or management boards of several clinical and neuroinformatics initiatives including the Ontario Brain Institute and a large-scale traumatic brain injury study, CENTER-TBI. Hill is author of more than 60 peer reviewed publications, multiple patents, and has given talks around the world on the topics of neuroinformatics, brain modeling and simulation, and on the cellular and synaptic mechanisms of conscious and unconscious brain states. An advocate of global collaboration on data sharing in brain research, Hill has actively worked with brain projects around the world to identify potential areas of collaboration and interaction. He has been quoted as saying "It takes the world to understand the brain." Hill has appeared in the press and in many documentaries about the brain, including on ARTE and the PBS documentary The Brain with David Eagleman, and has been interviewed in print and on radio and television programs including the CBC, CNN, and Bloomberg.