Sam Philipe opened a studio in Jerusalem in 1989. In addition to sculpture, he began to design jewelry and Jewish ceremonial art. Philipe's sculptures have been presented to government leaders around the world as gifts from the Israeli government. Philipe's statue "Jesus' blessing" was presented to Pope John Paul II on behalf of the Ministry of Religious Affairs. King Hussein of Jordan received a sculpture embodying Isaiah's prophecy of the lion and the lamb; George H.W. Bush, an elephant with the Star of David; and Princess Diana, a guardian angel. Yitzhak Rabin was presented with a sculpture depicting a paratrooper praying at the Western Wall. Outdoor sculptures by Philipe have been installed at various locations in Jerusalem, among them Ammunition Hill and Yad Labanim Soldiers House near Sacher Park. Many of his smaller sculptures, crafted from sterling silver and 24 karat gold, are mounted on polished stone bases using stones from the desert. Philipe often uses blocks of Jerusalem stone or black basalt from the Galilee as pedestals for his work. In February 2011, his bronze sculpture "Binding of Isaac" was displayed at Mamilla Mall as part of its "Stories of the Bible" exhibit. "Mother and child," a sculpture by Philipe, is displayed at the Revi Karuna Memorial Museum in Alleppey, India. His seven-foot bronze statue of the Prodigal son was installed in the museum courtyard in March 2012. "Reut" is a 10-foot bronze on Mount Scopus, overlooking the Judean Desert, depicting a combat medic embracing a wounded soldier. His inspiration for the work was an Israeli army doctor, Uri Freund, who was awarded the IDF medal of distinguished service for going out under heavy crossfire to rescue his wounded commander. To mark the 70th anniversary of the voyage of the SS Exodus, Philipe designed a memorial sculpture featuring a bronze relief of the Land of Israel. The monument was unveiled at Haifa Port in July 2017. Philipe's goal is to "reach God through art." He creates sculptures based on Bible themes in the belief that his work transports viewers back to ancient times and allows them to feel a connection to the Bible in their own life.
