Kea was born on 13 July 1917 in Milledgeville, Georgia. Her father was a gardener at the Ohio State Hospital for the Insane in Columbus where he was stabbed to death by a patient when Salaria was a baby. After his death the Kea family moved to Akron. Kea's mother returned to Georgia, leaving Salaria in the care of her three older brothers. Salaria wanted to pursue a career in nursing, but racial segregation policy of the day inhibited this goal in Ohio. She was forced to move on to New York City in 1930, where she graduated the Harlem Hospital School of Nursing in 1934. As a student she managed to end the segregation in the Harlem Hospital's staff dining room and was also able to improve the working conditions of African American nurses. After her graduation Kea stayed in New York and became the head nurse of Seaview Hospital. During her employment at Seaview she became politically active with the American left, eventually joining Communist Party USA in 1935.
Spanish Civil War
During the Second Italo-Ethiopian War in 1935 Kea and her fellow nurses started raising money to send medical supplies to Ethiopian troops. She was also anxious to work as a nurse in Ethiopia but the emperor Haile Selassie did not accept foreign volunteers. In 1936 she applied to join the American Red Cross to assist Midwest flood victims, but was rejected because of her ethnicity. Following the outbreak if the Spanish Civil War in 1936 Kea lectured across the United States to raise funds for the Second Spanish Republic. During this time Kea developed strong anti-fascist views. Kea decided to volunteer to serve in the International Brigades in the Spanish Civil War and joined the American Medical Bureau working with the Abraham Lincoln Battalion in March 1937. After her arrival in Spain, Kea helped establish a field hospital at Villa Paz near the Spanish capital Madrid. She was captured by the Spanish Nationalist Army but managed to escape with the help of International Brigade soldiers after being held for six weeks. In Villa Paz, Kea met an injured Irish soldier, John Patrick O’Reilly, whom she later married. In early 1938, Kea was transferred to different units in Aragon, Lerida and Barcelona and was herself injured in a Nationalist bombing raid. Her wounds were so severe that she was sent back to the United States in May 1938. The same year, Kea wrote her Spanish memoirs While Passing Through. They were published as a pamphlet named .
In 1940 John O’Reilly was allowed to immigrate the United States. He was soon drafted to serve in the military during World War II. In the beginning of 1944 Kea started working as a volunteer nurse for the United States Army as part of the first group of African American nurses the Army was allowed to recruit. In the United States Kea and O’Reilly experienced strong racism. In Akron they experienced personal threats and property damage, and Kea often referred to her time in the International Brigades as the best days of her life since they were free from discrimination. After the war the O'Reilly family lived in New York, where Kea worked in several hospitals coordinating staff desegregation. In 1973 the couple retired to Akron where Kea died on 18 May 1990.