In the early sixteenth century CE, Safsaf was incorporated into the Ottoman Empire, and by the 1596 tax records, it was a village in the nahiyah of Jira, part of Sanjak Safad. It had a population of 25 households, an estimated 138 persons, all Muslim. The villagers paid a fixed tax rate of 25% on several agricultural items, including wheat, barley, olives and fruits, as well as other types of produce, such as beehives and goats; a total of 3,714 akçe. A quarter of the revenue went to a waqf. In 1838 Safsaf was noted as a village in the Safad district, while in 1875 Victor Guérin described it as a village with fifteen Muslim families. In 1881 the PEF's Survey of Western Palestine described Safsaf as a small village situated on a plain, with a population of about 100. They also noted that "ornamented stones of a preexisting public building" had been built into the doorway of the villagemosque. The villagers cultivated olive and fig trees and vineyards. A population list from about 1887 showed Safsaf to have about 740 inhabitants, all Muslim.
Safsaf became a part of the British Mandate in 1922. During this time, the village lay on the eastern side of the Safad-Tarshiha highway and extended in a northeast-southwest direction. All the residents of Safsaf were Muslims. A mosque and several shops were located in the village center, and an elementary school was established during this period. Agriculture was the main economic activity, and it was both irrigated from springs and rainfed. Fruits and olives were cultivated on the land north of the village. In the 1922 census of Palestine Safsaf had a population of 521 Muslims, increasing in the 1931 census to 662, still all Muslims, in a total of 124 houses. In the 1945 statistics the population was 910 Muslims, with a total of 7,391 dunams of land, according to an official land and population survey. Of this, a total of 2,586 dunums were allotted to cereals; 769 dunums were irrigated or used for orchards, while a 72 dunams was built-up area.
1948, and aftermath
On October 29, 1948, Israeli forces assaulted the village as part of Operation Hiram. After the villagers surrendered, some 50-70 men were massacred while bound and four women reported being raped. The IDF records for this massacre remain classified. In 1949 Kfar Hoshen was established on village land, followed by Bar Yohai in 1979, also on village land. In 1992 the village site was described: "The site is overgrown with grass and scattered trees among which can be seen a few terraces and piles of stones from destroyed houses. A few houses are inhabited by Israelis. A fraction of surrounding land is cultivated by the settlements, and the rest is forested."
