Parents Annie and Arthur Pope are on the run as they were responsible for the anti-war protest bombing of a napalm laboratory in the 1970s. The incident accidentally blinded and paralyzed a janitor who wasn't supposed to be there. They've been on the run ever since, relying on an underground network of supporters who help them financially. At the time of the incident, their son Danny was two years old. As the film begins, he is in his late teens, and the family, now with younger son Harry, are again relocating and assuming new identities. Danny's overwhelming talent as a pianist catches the attention of his music teacher at school. The teacher begins to pry into Danny's personal life, particularly questioning why records from his previous school are unobtainable. While he pushes Danny to audition for Juilliard, Danny also falls in love with Lorna, the teacher's teenage daughter. As the pressure to have his own life and realize his own dreams intensifies, Danny reveals his family secret to Lorna. Meanwhile, Annie finds out about Danny's audition and begins to come to terms with the fact that she must let her son go and find his own way. This does not sit well with Arthur even as Annie risks their safety to contact her estranged father and arrange a home and life for Danny if they should decide to leave him behind. When Arthur hears on the radio that one of their underground colleagues has been shot and killed running from the authorities, he realizes that it is better for his son to pursue his dreams than to continue living a dangerous life on the run from crimes for which Danny bears no responsibility. The family leaves Danny behind and heads off for their next identity in a new town.
Running on Empty was released on September 9, 1988, in 22 theaters, where it grossed $215,157 on its opening weekend. It went on to make $2,835,116 in North America. Film critic Roger Ebert gave the film four out of four stars and called it "one of the best films of the year." In her review for The New York Times, Janet Maslin wrote, "The courtship between Danny and Lorna is staged especially disarmingly, with Mr. Phoenix and Miss Plimpton conveying a sweet, serious and believably gradual attraction." Newsweek magazine's David Ansen wrote, "A curious mix of soap opera and social history, Lumet's film shouldn't work, yet its fusion of oddly matched parts proves emotionally overpowering. You have to be pretty tough to resist it." Rotten Tomatoes gives the film an approval rating of 85% based on reviews from 13 critics. Metacritic gave the film a score of 67 based on 17 reviews, indicating "generally favorable reviews".