From 1973 to 1993, Gale was on the faculty of the UCLA School of Medicine in the Department of Medicine, Division of Hematology & Oncology, where he focused on the molecular biology, immunology and treatment of leukemia. He also developed the bone marrow transplant program supported by the NIH. At UCLA, he was active in the Department of Psychology, where he and his colleagues studied interactions among stress, immunity and cancer. From 1980 to 1997, Gale was Chairman of the Scientific Advisory Committee of the Center for International Blood and Marrow Transplant Research, an organization of more than 400 transplant centers in over 60 countries worldwide working together to analyze and advance knowledge about blood cell and bone marrow transplants. From 1989 to 2003 Gale chaired the Scientific Advisory Board of the Center for Advanced Studies in Leukemia, a charity funding innovation leukemia research. From 1986 to 1993, Gale was President of the Armand Hammer Center for Advanced Studies in Nuclear Energy and Health, a foundation supporting research on medical aspects of nuclear issues. From 1985 to 1990 he was the Wald Scholar in Biomedical Communications at UCLA. During this time he volunteered his expertise in bone marrow transplants to the USSR, for the victims of radiation poisoning incurred during the Chernobyl nuclear disaster. He aided Dr. Alexander Buranov and Dr. Angelina Guskova at Moscow's Hospital #6, a state hospital specializing in treating radiation sickness. From 1993 to 1999, Gale was Senior Physician and Corporate Director of Bone Marrow and Blood Cell Transplantation at Salick Health Care, Inc. in Los Angeles, a subsidiary of AstraZeneca. Gale was also responsible for developing cancer treatment guidelines and for studying medical aspects of managed cancer care. From 2000 to 2004 he was Senior Vice President for Medical Affairs at Antigenics Inc., in New York where he was responsible for design, implementation and analysis of clinical trials of cancer vaccines. He was also Senior Medical Consultant to Oxford Health Plans in areas of advanced medical technologies. From 2004 to 2007, Gale was Senior Vice President of Research for ZIOPHARM Oncology in Boston, Massachusetts and New York, New York, which he helped co-found. His focus was on developing and testing new cancer therapies. His activities included development and execution of clinical trials in blood and bone marrow cancers, transplantation and immune disorders. Since 2005 Gale has been a Visiting Professor of Haematology in the Centre for Haematology, Department of Immunology and Inflammation, Imperial College, London assigned to Hammersmith Hospital. He is an editor, co-editor and reviewer of many scientific journals in hematology, oncology, immunology, transplantation and internal medicine. Gale is regarded as a world expert on the medical response to nuclear and radiation accidents and has participated in rescue efforts at Chernobyl, Goiania, Tokaimura, Fukushima and others. In 2012, after extensive analysis of the Japanese data, he said that "the increased risk of cancer incidence would be only 0.002 percent for a member of the Japanese public".
Bone marrow transplantation
Gale has contributed to basic science and clinical research in bone marrow transplantation where he made contributions to understanding the immune-mediated anti-leukemia effects of transplants. He has also advanced understanding of other complex immune effects of transplants in humans, like graft-versus-host disease and post-transplant immune deficiency. He has worked on alternate sources of hematopoietic stem cells including fetal liver transplants.
Humanitarian activities
In 1986, he was asked by the government of the Soviet Union to coordinate medical relief efforts for victims of the Chernobyl disaster. In 1987, he was asked by the government of Brazil to coordinate medical relief efforts for the Goiânia accident. In 1988, he was part of the U.S. medical emergency team sent in the aftermath of the earthquake in Armenia. In 1999 he was asked by the government of Japan to help treat victims of the Tokaimura nuclear accident. In 2011 Gale was called to Japan to deal with medical consequences of the Fukushima nuclear power station accident. He met with members of the Prime Minister's office on several occasions and has addressed the Diet on three occasions. Gale has also been a neutral war observer for the governments of Croatia and Armenia and a medical consultant to the government of Tatarstan. Gale has received several awards for his humanitarian activities including the Olender Peace Prize, City of Los Angeles Humanitarian Award and Myasthenia Gravis Foundation Humanitarian Award.
Publications
Gale has published over 1150 scientific articles and more than 20 books, mostly on leukemia, transplantation, cancer immunology, and radiation health effects and accident response. He has written on medical topics, nuclear energy and weapons and politics of US-Soviet relations in articles for The New York Times, Los Angeles Times, Washington Post, USA Today and Wall Street Journal. In addition to his academic publications, Gale has written popular books on the Chernobyl accident and US nuclear energy policy. He has written parts of screenplays for, and appeared in, several movies including , Fat Man and Little Boy, and City of Joy. His latest book, Radiation: What it is, What you need to know, with Eric Lax, was published in February 2013.
