Nemiroff's research interests include gamma-ray bursts, gravitational lensing, sky monitoring, and cosmology. Among other findings, his research on gamma-ray bursts:
showed that gamma-ray bursts are consistent with a cosmological distance scale origin before they were discovered to be so distant
led a team that, along with others, showed a lack of energy-dependence in the speed of photons from distant gamma-ray bursts which implies, in contrast to some theories of quantum gravity, that the universe is smooth below the Planck-length scale, as Einstein had predicted
In 1999 Nemiroff and colleague Bruce Rafert published a paper showing that continuous astronomical sky monitors could soon become a reality. With students, Nemiroff's initial night sky monitor was an automatically repeating SLR camera with a fisheye lens deployed to Michigan Technological Universityin 1999, Nemiroff then led a group that designed, built, and deployed the first astronomical all sky optical web monitor, dubbed a CONtinuous CAMera, and in 2000 deployed it to Kitt Peak National Observatory. By the mid-2000s, most major astronomical observatories deployed CONCAM or CONCAM-like devices together capable of monitoring most of the night sky most of the time. Astronomical all sky web monitors are now common at astronomical observing sites. Subsequent collaborative efforts in astronomical deep-sky monitoring now include Pan-STARRs and LSST. In 1986, he predicted the likelihood of microlensing and calculated basic microlensing induced light curves for several possible lens-source configurations in his 1987 thesis. Among his microlensing findings, he, along with others:
predicted before observational recovery that microlensing light curves can effectively resolve the surface of source stars
showed that microlensing boosts the brightnesses of stars actually below the magnitude limit of a survey over the survey limit
Nemiroff and graduate student Bijunath R. Patla showed that the Sun is a "very interesting gravitational lens," and Nemiroff found that GRB pulses start at the same time at every energy and that they are scale invariant over energy. His complete publication list is .
Nemiroff is one of two creators and editors of the Astronomy Picture of the Day website. Started in 1995 by Nemiroff and Dr. Jerry T. Bonnell, is consistently among the most popular astronomy sites. Its home page typically receives over one million hits per day; APOD has served over one billion images since its start. It is translated into more than 20 languages and has social media outlets on Facebook, Google+, Twitter, and various apps. Nemiroff and Bonnell were awarded the 2015 Klumpke-Roberts Award by the Astronomical Society of the Pacific "for outstanding contributions to public understanding and appreciation of astronomy" for their work on APOD.