Luis del Castillo Negrete came to Alta California in 1834 as a member of the Híjar-Padrés Colony. He was an advisor to Governor Mariano Chico, and returned to Mexico in 1836. His brother, Francisco Javier del Castillo Negrete, received the six square league Rancho Quién Sabe in 1836 from Governor Nicolás Gutiérrez. In 1839, the land was re-granted by Governor Alvarado to Manuel Larios and Juan Miguel Anzar. Anzar paid Larios to oversee the property. In 1848 the two men agreed to divide the grant; Larios took Rancho Santa Ana, and Anzar took Rancho Quién Sabe. Later, when title to the land was being determined, the courts ruled that Anzar and Larios owned equal shares.
Manuel Salvador Larios
Manuel Salvador Larios was married three times; first to Maria Antonia del Carmen Pacheco, then secondly to Guadalupe Castro, and thirdly to Maria Rosario Armas de Higuera. When Larios died in 1865, his two surviving minor children were Martin del Patricinio and Estolano. Rosario Armas de Larios, with her son, Estolano Larios, and her Higuera children from a previous marriage moved to New Idria
Juan Miguel Anzar
Juan Miguel Anzar was the brother of padre Jose Antonio Anzar who served at the Mission San Juan Bautista until he returned to Mexico in 1835. Juan Miguel Anzar was the grantee of Rancho Los Aromitas y Agua Caliente in 1835. Juan Miguel Anzar married Maria Antonia Castro. When Juan Miguel Anzar died in 1853, he held title to Rancho Los Aromitas y Agua Caliente, Rancho Santa Ana y Quién Sabe, Rancho Real de los Aguilas and Rancho Los Carneros. His widow, Maria Antonia Castro de Anzar, married Frederick A. McDougall. Maria Antonia Castro de Anzar de MacDougall died in 1855, leaving McDougal and her children as heirs.
Post-statehood
With the cession of California to the United States following the Mexican-American War, the 1848 Treaty of Guadalupe Hidalgo provided that the land grants would be honored. As required by the Land Act of 1851, a claim for Rancho Santa Ana y Quién Sabe was filed with the Public Land Commission in 1852, and the combined grant was patented to Manuel Larios and Juan Miguel Anzar in 1860. A claim based on the Nicolas Gutierrez grant of six square leagues to Luis del Castillo Negrete, was filed by Josefa Morales del Castillo Negrete with the Land Commission in 1852, but was rejected. A claim based on the Nicolas Gutierrez grant of six square leagues to Francisco Javier del Castillo Negrete filed by Francisco Castillo Negrete with the Land Commission in 1852 was also rejected. In 1866, the heirs of Manuel Larios sold of Rancho Santa Ana y Quién Sabe to Joaquín Bolado and his business partner José G. Arques. In 1869, Juan Francisco Anzar sold Rancho Santa Ana and Quién Sabe to Estanislao Hernández.
