Raf kinase inhibitor protein
The Raf kinase inhibitor protein is a kinase inhibitor protein, that regulates many signaling pathways within the cell. RKIP is a member of the phosphatidylethanolamine-binding protein family and has displayed disruptive regulation on the Raf-1-MEK1/2, ERK1/2 and NF-kappaB signalling pathways, by interaction with the Raf-1 kinase.
RKIP has also been shown to inhibit G protein coupled receptor kinases when phosphorylated by protein kinase C. Via this mechanism it has been shown to exert beneficial effects on cardiac structure and function.
