Quinazolinone
Quinazolinone is a heterocyclic chemical compound, a quinazoline with a keto group. There are two structural isomers, 2-quinazolinone and 4-quinazolinone, with the 4-isomer being the more common.Derivatives
Jafari et al. state that "One of the most important heterocycles in medicinal chemistry are quinazolines possessing wide spectrum of biological properties like antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-HIV, anticancerous and analgesic activities. This skeleton is an important pharmacophore considered as a privileged structure." Their review discusses quinazolines and quinazolinone derivatives with antimicrobial and cytotoxic activities.
Quinazolinone drugs that function as hypnotic/sedatives usually contain a 4-quinazolinone core with a 2-substituted phenyl group at nitrogen atom 3.
