The film opens with an infomercial, given by Dick Dupre played by John C. McGinley, which Larry and Rico are watching. Larry and Rico are two stoners who live in a one-room apartment, and after watching the entire infomercial, they decide to start a "tiny classified ads" business. This is a running gag throughout the film. Each time they explain their new "business," someone asks, "Ads for what?", and they respond confidently, "That's not the point! It's complex" or "The ads themselves... they generate income", simply quoting the infomercial. After the two are locked out of their apartment by their landlord Lance for being late on rent, the two are stuck for a way to get cable television so they can watch The Shawshank Redemption during a 24-hourmarathon on TNT. Larry, in despair because his car won't start and they will miss "the Shank," remembers a rehab brochure he picked up, and decides that he had reached "his bottom", and needs to go to rehab. Rico decides to go with him after he sees in the brochure that the clinic has basic cable. In rehab, the two stoners quickly find themselves out of place among the harddrug addicts there, not to mention the counselors. Beside this, they also find out that the brochure was false, and they only have eight channels and no TNT. After spending their first night messing with junkies and each having a one-night stand with the women in rehab, the two are kicked out. They decide to go to see Big Daddy, a wealthy acquaintance of theirs. Big Daddy thinks that Larry and Rico are two guys his girlfriend Elise has set up for his sale of an expensive collection of antique Indian Head pennies. The buyer is an aspiring rapper named Cool Crush Ice Killa, who wants to meet Larry and Rico at a bus station with the money. They forget the coins in Larry's car, and in a panic they run from the bus station with the money, with Ice Killa chasing them. They go back to Big Daddy's, where Ice Killa, who has a great fear of dogs, is chased up a tree by Big Daddy's trained guard dog. Larry, Rico, and Big Daddy then find out that Elise and Ice Killa were trying to steal the coins. Big Daddy then asks Larry and Rico to work for him in his investment in beachfront property in Nicaragua. At the airport, they run into Dupre, whose infomercials turned out to be a scam, and is now also investing in Nicaragua. The movie ends with another infomercial, this time featuring Dupre, Larry and Rico. Back at the apartment, two new stoners are being told off by Lance for being late on rent, when Larry and Rico appear on the TV telling of their new fortunes. The new tenants hail them as brilliant, yelling "Nicaragua!" victoriously. In complete disbelief, Lance decides to hit their joint.