Pro-hevein


Pro-hevein is a wound-induced and a lectin-like protein from Hevea brasiliensis where it is involved in the coagulation of latex.
The 187 amino-acid propeptide pro-hevein is cleaved in two fragments: a N-terminal 43 amino-acid Hevein bearing a chitin-binding type-1 domain that binds to chitin and a 138 amino-acid Win-like protein bearing a Barwin domain.
It has antifungal properties.

Role of hevein in latex allergy

Hevein is the main IgE-binding epitope of the major latex allergen prohevein as are hevein-like protein domains in fruit class I chitinases. Therefore it is a possible cause for allergen cross-reactivity between latex and banana or other fruits like chestnuts or avocadoes. Hevein-like genes can be found in many plants including Arabidopsis thaliana.
Hevein is called Hev b 6 under the WHO allergen nomenclature. There are three entries under this classification, corresponding to the conformational epitopes Hev b 6.01, Hev b 6.03, and Hev b 6.03. They correspond to the full Pro-Havein protein, the matur Hevein, and the C-terminal Barwin domain respectively.